Emerging biomarkers and molecular targets for precision medicine in cervical cancer

被引：24

作者：

Garg, Pankaj ^{[1
]}

Krishna, Madhu ^{[2
,3
,4
,5
]}

Subbalakshmi, Ayalur Raghu ^{[2
,3
,4
,5
]}

Ramisetty, Sravani ^{[2
,3
,4
,5
]}

Mohanty, Atish ^{[2
,3
,4
,5
]}

Kulkarni, Prakash ^{[2
,3
,4
,5
]}

Horne, David ^{[5
,6
]}

Salgia, Ravi ^{[2
,3
,4
,5
]}

Singhal, Sharad S. ^{[2
,3
,4
,5
]}

机构：

[1] GLA Univ, Dept Chem, Mathura 281406, Uttar Pradesh, India

[2] Comprehens Canc Ctr, Dept Med Oncol, Duarte, CA 91010 USA

[3] Comprehens Canc Ctr, Dept Therapeut Res, Duarte, CA 91010 USA

[4] Comprehens Canc Ctr, Beckman Res Inst City Hope, Duarte, CA 91010 USA

[5] Natl Med Ctr, Duarte, CA 91010 USA

[6] Comprehens Canc Ctr, Beckman Res Inst City Hope, Dept Mol Med, Duarte, CA 91010 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2024年 / 1879卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Gynecological cancers; Biomarkers; Molecular pathways; Genetic alterations; Precision medicine; DNA METHYLATION; INTRAEPITHELIAL NEOPLASIA; HUMAN-PAPILLOMAVIRUS; PATHWAY; DIAGNOSIS; PROTEIN; MECHANISMS; EXPRESSION; OVEREXPRESSION; CARCINOGENESIS;

D O I：

10.1016/j.bbcan.2024.189106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cervical cancer remains a significant global health burden, necessitating innovative approaches for improved diagnostics and personalized treatment strategies. Precision medicine has emerged as a promising paradigm, leveraging biomarkers and molecular targets to tailor therapy to individual patients. This review explores the landscape of emerging biomarkers and molecular targets in cervical cancer, highlighting their potential implications for precision medicine. By integrating these biomarkers into comprehensive diagnostic algorithms, clinicians can identify high-risk patients at an earlier stage, enabling timely intervention and improved patient outcomes. Furthermore, the identification of specific molecular targets has paved the way for the development of targeted therapies aimed at disrupting key pathways implicated in cervical carcinogenesis. In conclusion, the evolving landscape of biomarkers and molecular targets presents exciting opportunities for advancing precision medicine in cervical cancer. By harnessing these insights, clinicians can optimize treatment selection, enhance patient outcomes, and ultimately transform the management of this devastating disease.

引用

页数：12

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