Advances in targeted liquid chromatography-tandem mass spectrometry methods for endocannabinoid and N-acylethanolamine quantification in biological matrices: A systematic review

被引：5
作者：
Hamzah, Khalisa Amir [1 ]
Turner, Natalie [2 ]
Nichols, David [3 ]
Ney, Luke J. [1 ]
机构：
[1] Queensland Univ Technol, Sch Psychol & Counselling, Dept Hlth, Kelvin Grove, Qld, Australia
[2] Queensland Univ Technol, Ctr Childrens Hlth Res, Kelvin Grove, Qld, Australia
[3] Univ Tasmania, Cent Sci Lab, Sci & Engn, Hobart, Tas, Australia
来源：
MASS SPECTROMETRY REVIEWS | 2025年 / 44卷 / 03期
关键词：
anandamide; endocannabinoids; LC-MS; liquid chromatography; mass spectrometry; LC-MS/MS; 2-ARACHIDONOYLGLYCEROL LEVELS; ENDOGENOUS CANNABINOIDS; FATTY-ACID; PLASMA; ANANDAMIDE; BRAIN; GLUCOCORTICOIDS; MASTICATION; RECEPTOR;
D O I：
10.1002/mas.21897
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Liquid chromatography paired with tandem mass spectrometry (LC-MS/MS) is the gold standard in measurement of endocannabinoid concentrations in biomatrices. We conducted a systematic review of literature to identify advances in targeted LC-MS/MS methods in the period 2017-2024. We found that LC-MS/MS methods for endocannabinoid quantification are relatively consistent both across time and across biomatrices. Recent advances have primarily been in three areas: (1) sample preparation techniques, specific to the chosen biomatrix; (2) the range of biomatrices tested, recently favoring blood matrices; and (3) the breadth of endocannabinoid and endocannabinoid-like analytes incorporated into assays. This review provides a summary of the recent literature and a guide for researchers looking to establish the best methods for quantifying endocannabinoids in a range of biomatrices.
引用
收藏
页码：513 / 538
页数：26
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