Advances in targeted liquid chromatography-tandem mass spectrometry methods for endocannabinoid and N-acylethanolamine quantification in biological matrices: A systematic review

被引：5

作者：

Hamzah, Khalisa Amir ^{[1
]}

Turner, Natalie ^{[2
]}

Nichols, David ^{[3
]}

Ney, Luke J. ^{[1
]}

机构：

[1] Queensland Univ Technol, Sch Psychol & Counselling, Dept Hlth, Kelvin Grove, Qld, Australia

[2] Queensland Univ Technol, Ctr Childrens Hlth Res, Kelvin Grove, Qld, Australia

[3] Univ Tasmania, Cent Sci Lab, Sci & Engn, Hobart, Tas, Australia

来源：

MASS SPECTROMETRY REVIEWS | 2025年 / 44卷 / 03期

关键词：

anandamide; endocannabinoids; LC-MS; liquid chromatography; mass spectrometry; LC-MS/MS; 2-ARACHIDONOYLGLYCEROL LEVELS; ENDOGENOUS CANNABINOIDS; FATTY-ACID; PLASMA; ANANDAMIDE; BRAIN; GLUCOCORTICOIDS; MASTICATION; RECEPTOR;

D O I：

10.1002/mas.21897

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Liquid chromatography paired with tandem mass spectrometry (LC-MS/MS) is the gold standard in measurement of endocannabinoid concentrations in biomatrices. We conducted a systematic review of literature to identify advances in targeted LC-MS/MS methods in the period 2017-2024. We found that LC-MS/MS methods for endocannabinoid quantification are relatively consistent both across time and across biomatrices. Recent advances have primarily been in three areas: (1) sample preparation techniques, specific to the chosen biomatrix; (2) the range of biomatrices tested, recently favoring blood matrices; and (3) the breadth of endocannabinoid and endocannabinoid-like analytes incorporated into assays. This review provides a summary of the recent literature and a guide for researchers looking to establish the best methods for quantifying endocannabinoids in a range of biomatrices.

引用

收藏

页码：513 / 538

页数：26

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