Formin Binding Protein 1 (FNBP1) regulates non-canonical Wnt signaling and vertebrate gastrulation (12 words)

被引:1
|
作者
Zeni, Courtney [1 ]
Komiya, Yuko [1 ]
Habas, Raymond [1 ]
机构
[1] Temple Univ, Dept Biol, 1900 North 12th St,BioLife Room 201, Philadelphia, PA 19122 USA
关键词
PLANAR CELL POLARITY; CONVERGENT EXTENSION MOVEMENTS; BETA-CATENIN; TISSUE POLARITY; AXIS FORMATION; DAAM1; XENOPUS; ACTIVATION; EFFECTOR; ACTIN;
D O I
10.1016/j.ydbio.2024.06.019
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Formin protein Daam1 is required for Wnt-induced cytoskeletal changes during gastrulation, though how it accomplishes this remains unresolved. Here we report the characterization of Formin Binding Protein 1 (FNBP1) as a binding partner of Daam1. The interaction of Daam1 with FNBP1 and its domains required for this interaction were delineated. Immunofluorescence studies showed FNBP1 co-localizes with Daam1, and is an integral component of the actin cytoskeletal complex that is responsive to Wnt stimulation. Specifically, FNBP1 can induce intracellular tubule-like structures and localize to focal adhesions suggesting a role for FNBP1 in cell migration. Functional FNBP1 studies in Xenopus embryos uncover a critical role for FNBP1 in regulating vertebrate gastrulation. Additionally, suboptimal doses of Daam1 and FNBP1 synergize to produce severe gastrulation defects, indicating FNBP1 and Daam1 may function within the same signaling pathway. These results together show FNBP1 is an integral component of Daam1-regulated non-canonical Wnt signaling required for vertebrate gastrulation.
引用
收藏
页码:18 / 29
页数:12
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