Efficacy of Polymyxin B Hemoperfusion for Treatment of Sepsis

被引：2
作者：
Ghosh, Indranil [1 ]
Sangha, Sukhwinder [2 ]
Pandey, Gaurav [3 ]
Srivastava, Atul [4 ]
机构：
[1] Army Hosp R&R, Dept Med, New Delhi, India
[2] Command Hosp WC, Dept Med & Nephrol, Panchkula, Haryana, India
[3] SNM Hosp, ITBP, Leh, Ladakh, India
[4] Command Hosp SC, Dept Nephrol Med & Nephrol, Pune, India
来源：
INDIAN JOURNAL OF CRITICAL CARE MEDICINE | 2024年 / 28卷 / 10期
关键词：
Intensive care unit; Mortality; Polymyxin B; Sepsis; Sequential organ failure assessment; SEPTIC SHOCK; HYPERGLYCEMIA; THERAPY;
D O I：
10.5005/jp-journals-10071-24805
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Objectives: To study the efficacy of polymyxin B hemoperfusion in addition to standard care for sepsis treatment. Materials and methods: Fifty sepsis patients (mean age 54.26 +/- 14.64 years; 68% males) were randomized to either the case group (n n = 25; receiving Polymyxin B hemoperfusion in addition to standard ICU care) or the control group (n n = 25; receiving standard ICU care only). The patients were followed up at frequent intervals of 6, 12, 24, 48, and 72 hours. A last follow-up on day 7 was done. The duration of the ICU stay and survival until day 7 were recorded. Changes in clinical and biochemical parameters were also noted and compared. Results: Mean sequential organ failure assessment (SOFA) scores at admission were 3.44 +/- 1.00 and 2.80 +/- 0.82, respectively, in cases and controls. Cases as compared to controls showed faster, and sustainable improvement. No significant difference between the two groups was seen for mortality at day 7. Conclusion: Polymyxin B hemoperfusion tends to show a faster recovery and a non-significant trend towards reduced mortality in ICU-admitted sepsis patients.
引用
收藏
页码：930 / 934
页数：5
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