Results of International, Double-Blind, Randomized, Placebo-Controlled, Phase IIa Study of Interleukin-1 Blockade With RPH-104 (Goflikicept) in Patients With ST-Segment-Elevation Myocardial Infarction (STEMI)

被引：9

作者：

Abbate, Antonio ^{[1
]}

Van Tassell, Benjamin ^{[2
]}

Bogin, Vlad ^{[3
]}

Markley, Roshanak ^{[2
]}

Pevzner, Dmitry V. ^{[4
]}

Cremer, Paul C. ^{[5
]}

Meray, Imad ^{[6
]}

Privalov, Dmitry V. ^{[7
]}

Taylor, Angela ^{[1
]}

Grishin, Sergey A. ^{[8
]}

Egorova, Alina N. ^{[8
]}

Ponomar, Ekaterina G. ^{[8
]}

Lavrovsky, Yan ^{[9
]}

Samsonov, Mikhail Yu ^{[8
]}

机构：

[1] Univ Virginia, Dept Med, Charlottesville, VA USA

[2] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA USA

[3] Cromos Pharma LLC, Portland, OR USA

[4] Minist Healthcare Russian Federat, Emergency Cardiol Dept, Natl Med Res Ctr Cardiol, Moscow, Russia

[5] Cleveland Clin, Dept Cardiovasc Med, Heart Vasc & Thorac Inst, Cleveland, OH USA

[6] Peoples Friendship Univ Russia na Patrice Lumumba, Dept Internal Med, Moscow, Russia

[7] City Clin Hosp 51 Moscow, Cardiol & Intens Therapy Dept, Healthcare Dept, Moscow, Russia

[8] R Pharm JSC, Med Dept, Moscow, Russia

[9] R Pharm Overseas Inc, La Jolla, CA USA

来源：

CIRCULATION | 2024年 / 150卷 / 07期

关键词：

cytokine; inflammation; myocardial infarction;

D O I：

10.1161/CIRCULATIONAHA.124.069396

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：580 / 582

页数：3

共 5 条

[1] Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease [J].

Abbate, Antonio ;

Toldo, Stefano ;

Marchetti, Carlo ;

Kron, Jordana ;

Van Tassell, Benjamin W. ;

Dinarello, Charles A. .

CIRCULATION RESEARCH, 2020, 126 (09) :1260-1280

[2] Interleukin-1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST-Segment-Elevation Myocardial Infarction [J].

Abbate, Antonio ;

Trankle, Cory R. ;

Buckley, Leo F. ;

Lipinski, Michael J. ;

Appleton, Darryn ;

Kadariya, Dinesh ;

Canada, Justin M. ;

Carbone, Salvatore ;

Roberts, Charlotte S. ;

Abouzaki, Nayef ;

Melchior, Ryan ;

Christopher, Sanah ;

Turlington, Jeremy ;

Mueller, George ;

Garnett, James ;

Thomas, Christopher ;

Markley, Roshanak ;

Wohlford, George F. ;

Puckett, Laura ;

de Chazal, Horacio Medina ;

Chiabrando, Juan G. ;

Bressi, Edoardo ;

Del Buono, Marco Giuseppe ;

Schatz, Aaron ;

Vo, Chau ;

Dixon, Dave L. ;

Biondi-Zoccai, Giuseppe G. ;

Kontos, Michael C. ;

Van Tassell, Benjamin W. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2020, 9 (05)

[3]

Dmitrieva A., 2018, IMMUNOME RES, V14, P47, DOI [10.4172/1745-7580-c1-014, DOI 10.4172/1745-7580-C1-014]

[4] Treatment of Idiopathic Recurrent Pericarditis With Goflikicept Phase II/III Study Results [J].

Myachikova, Valentina Yu. ;

Maslyanskiy, Alexey L. ;

Moiseeva, Olga M. ;

V. Vinogradova, Oksana ;

V. Gleykina, Ekaterina ;

Lavrovsky, Yan ;

Abbate, Antonio ;

Grishin, Sergey A. ;

Egorova, Alina N. ;

Schedrova, Margarita L. ;

Samsonov, Mikhail Yu. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2023, 82 (01) :30-40

[5] Interleukin-1 blockade with RPH-104 in patients with acute ST-elevation myocardial infarction: study design and rationale [J].

Samsonov, M. ;

Bogin, V ;

Van Tassell, B. W. ;

Abbate, A. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2021, 19 (01)

← 1 →