Non-coding RNAs as Key Regulators of the Notch Signaling Pathway in Glioblastoma: Diagnostic, Prognostic, and Therapeutic Targets

被引:0
作者
Shahcheraghi, Seyed Hossein [1 ,2 ]
Asl, Elmira Roshani [3 ]
Lotfi, Malihe [4 ]
Ayatollahi, Jamshid [2 ,5 ]
Khaleghinejad, Seyed Hossein [6 ]
Aljabali, Alaa A. A. [7 ]
Bakshi, Hamid A. [8 ]
El-Tanani, Mohamed [9 ]
Charbe, Nitin B. [10 ]
Serrano-Aroca, Angel [11 ]
Mishra, Vijay [12 ]
Mishra, Yachana [13 ]
Goyal, Rohit [14 ]
Hromic-Jahjefendic, Altijana [15 ]
Uversky, Vladimir N. [16 ]
Lotfi, Marzieh [17 ]
Tambuwala, Murtaza M. [18 ]
机构
[1] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Genet, Yazd, Iran
[2] Shahid Sadoughi Univ Med Sci, Shahid Sadoughi Hosp, Infect Dis Res Ctr, Yazd, Iran
[3] Saveh Univ Med Sci, Social Determinants Hlth Res Ctr, Saveh, Iran
[4] Mashhad Univ Med Sci, Sch Med, Dept Med Genet & Mol Med, Mashhad, Iran
[5] Shahid Sadoughi Univ Med Sci, Hematol & Oncol Res Ctr, Yazd, Iran
[6] Shiraz Univ, Coll Sci, Dept Biol, Shiraz, Iran
[7] Yarmouk Univ, Dept Pharmaceut & Pharmaceut Technol, Irbid, Jordan
[8] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA
[9] Ras Al Khaimah Med & Hlth Sci Univ, Ras Al Khaymah, U Arab Emirates
[10] Univ Florida, Ctr Pharmacometr & Syst Pharmacol, Dept Pharmaceut Lake Nona, Orlando, FL USA
[11] Univ Catolica Valencia, Ctr Invest Traslac San Alberto Magno, Biomat & Bioengn Lab, Valencia 46001, Spain
[12] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India
[13] Lovely Profess Univ, Sch Bioengn & Biosci, Dept Zool, Phagwara 144411, Punjab, India
[14] Shoolini Univ Biotechnol & Management Sci, Sch Pharmaceut Sci, Solan, India
[15] Int Univ Sarajevo, Fac Engn & Nat Sci, Dept Genet & Bioengn, Hrasnicka cesta 15, Sarajevo 71000, Bosnia & Herceg
[16] Univ S Florida, Dept Mol Med, Tampa, FL 33612 USA
[17] Shahid Sadoughi Univ Med Sci, Reprod Sci Inst, Abort Res Ctr, Yazd, Iran
[18] Univ Lincoln, Lincoln Med Sch, Brayford Pool Campus, Lincoln LN6 7TS, England
关键词
Glioblastoma; Notch signaling; lncRNAs; miRNAs; central nervous system; brain malignancy; EGF RECEPTOR GENE; STEM-LIKE CELLS; BRAIN-TUMORS; DOWN-REGULATION; GLIOMA-CELLS; STRESS-RESPONSE; TENASCIN-C; ACTIVATION; EXPRESSION; APOPTOSIS;
D O I
10.2174/0118715273277458231213063147
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Glioblastoma multiforme (GBM) is a highly invasive brain malignancy originating from astrocytes, accounting for approximately 30% of central nervous system malignancies. Despite advancements in therapeutic strategies including surgery, chemotherapy, and radiopharmaceutical drugs, the prognosis for GBM patients remains dismal. The aggressive nature of GBM necessitates the identification of molecular targets and the exploration of effective treatments to inhibit its proliferation. The Notch signaling pathway, which plays a critical role in cellular homeostasis, becomes deregulated in GBM, leading to increased expression of pathway target genes such as MYC, Hes1, and Hey1, thereby promoting cellular proliferation and differentiation. Recent research has highlighted the regulatory role of non-coding RNAs (ncRNAs) in modulating Notch signaling by targeting critical mRNA expression at the post-transcriptional or transcriptional levels. Specifically, various types of ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been shown to control multiple target genes and significantly contribute to the carcinogenesis of GBM. Furthermore, these ncRNAs hold promise as prognostic and predictive markers for GBM. This review aims to summarize the latest studies investigating the regulatory effects of ncRNAs on the Notch signaling pathway in GBM.
引用
收藏
页码:1203 / 1216
页数:14
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