Cushing's Storm: A Case of Paraneoplastic Cushing's Syndrome-Induced Seizures Treated With Continuous Etomidate Infusion

被引：0

作者：

Marsalisi, Christopher B. ^{[1
]}

Zhang, Yixin ^{[2
]}

Sousou, John M. ^{[1
]}

Lam, Loruanma ^{[1
]}

Burstiner, Landen S. ^{[1
]}

Ferreira, Jason ^{[3
]}

Najjar, Nimeh ^{[4
]}

机构：

[1] Univ Florida, Coll Med, Internal Med, Jacksonville, FL 32209 USA

[2] Univ Florida, Coll Med, Cardiol, Jacksonville, FL USA

[3] Univ Florida, Coll Med, Pharmacol, Jacksonville, FL USA

[4] Univ Florida, Coll Med, Pulm & Crit Care Med, Jacksonville, FL USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 09期

关键词：

intensive and critical care; ectopic cushing's syndrome; small cell lung cancer (sclc); clinical pharmacology; medical icu; MANAGEMENT;

D O I：

10.7759/cureus.69193

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 67-year-old female presented with abdominal pain, nausea, vomiting, and unintentional weight loss. Further work-up revealed elevated serum cortisol, hypokalemia, and metabolic alkalosis in the setting of paraneoplastic Cushing's syndrome secondary to small lung cancer. The patient then developed refractory convulsive epileptic seizure despite being on multiple anti-epileptic medications. Here, we present a unique case where continuous etomidate infusion was used to lower serum cortisol, as adrenal insufficiency is associated with etomidate use. This case emphasizes how drug side effects can be used to achieve a desired treatment outcome.

引用

页数：6

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