Predictors of distant metastatic recurrence in head and neck cutaneous squamous cell carcinoma with lymph node metastases treated with curative intent: A multicenter study

被引：1

作者：

Ebrahimi, Ardalan ^{[1
,2
,3
]}

Gupta, Ruta ^{[4
,5
]}

Mcdowell, Lachlan ^{[6
,7
]}

Magarey, Matthew J. R. ^{[8
,9
]}

Smith, Paul N. ^{[1
]}

Schulte, Klaus-Martin ^{[1
]}

Perriman, Diana M. ^{[1
]}

Veness, Michael ^{[5
,10
]}

Porceddu, Sandro ^{[11
,12
]}

Low, Tsu-Hui Hubert ^{[2
,5
]}

Fowler, Allan ^{[13
]}

Clark, Jonathan R. ^{[2
,5
,14
]}

机构：

[1] Australian Natl Univ, Coll Hlth & Med, Med Sch, Canberra, ACT 2601, Australia

[2] Sydney Head & Neck Canc Inst, Dept Head & Neck Surg, Chris OBrien Lifehouse, Sydney, NSW, Australia

[3] Canberra Hosp, Dept Head & Neck Surg, Canberra, ACT, Australia

[4] Royal Prince Alfred Hosp, Dept Tissue Pathol & Diagnost Oncol, Sydney, NSW, Australia

[5] Univ Sydney, Fac Med & Hlth Sci, Sydney Med Sch, Sydney, NSW, Australia

[6] Peter MacCallum Canc Ctr, Dept Radiat Oncol, Melbourne, Vic, Australia

[7] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

[8] Peter MacCallum Canc Ctr, Dept Surg Oncol, Melbourne, Vic, Australia

[9] Univ Melbourne, Dept Med Educ, Melbourne, Vic, Australia

[10] Westmead Hosp, Dept Radiat Oncol, Sydney, NSW, Australia

[11] Princess Alexandra Hosp, Dept Radiat Oncol, Brisbane, Qld, Australia

[12] Univ Queensland, Sch Med, Brisbane, Qld, Australia

[13] Liverpool Hosp, Dept Radiat Oncol, Sydney, NSW, Australia

[14] Royal Prince Alfred Inst Acad Surg, Sydney Local Hlth Dist, Camperdown, NSW, Australia

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2025年 / 47卷 / 01期

关键词：

cutaneous squamous cell carcinoma; distant metastases; head and neck cancer; lymph node metastasis; prognosis; PULMONARY METASTASES; SURGICAL RESECTION; SURVIVAL;

D O I：

10.1002/hed.27912

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: We aimed to identify predictors of distant metastatic recurrence (DMR) in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC) with nodal metastases treated with curative intent. Methods: Predictors of DMR were identified using Cox regression in a multicenter study of 1151 patients. Results: The 5-year risk of DMR was 9.6%. On multivariate analysis, immunosuppression (HR 2.93; 95% CI: 1.70-5.05; p < 0.001), nodal size >6 cm [versus <= 3 cm (HR 2.77; 95% CI: 1.09-7.03; p = 0.032)], >= 5 nodal metastases [versus 1-2 (HR 2.79; 95% CI: 1.63-4.78; p < 0.001)], and bilateral disease (HR 3.11; 95% CI: 1.40-6.90; p = 0.005) predicted DMR. A DMR risk score was developed that stratified risk from 6.6% (no risk factors) to 100% (>= 3 risk factors) (p < 0.001). Conclusions: The risk of DMR in nodal metastatic HNcSCC increases with immunosuppression, nodal size >6 cm, >= 5 nodal metastases, and bilateral disease. A simple DMR risk score estimated prior to treatment may be clinically useful.

引用

页码：254 / 262

页数：9

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