Epigallocatechin gallate improves oleic acid-induced hepatic steatosis in laying hen hepatocytes via the MAPK pathway

被引：5

作者：

Zhu, Yifeng ^{[1
]}

Zhao, Xiyu ^{[2
,3
]}

Li, Xinyan ^{[2
,3
]}

Hu, Chengfang ^{[2
,3
]}

Zhang, Yao ^{[2
,3
]}

Yin, Huadong ^{[2
,3
]}

机构：

[1] Sichuan Agr Univ, Inst Anim Nutr, Key Lab Anim Dis & Resistance Nutr China, Minist Educ, Chengdu 611130, Sichuan, Peoples R China

[2] Sichuan Agr Univ, Coll Anim Sci & Technol, Key Lab Livestock & Poultry Multiom, Minist Agr & Rural Affairs, Chengdu 611130, Sichuan, Peoples R China

[3] Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key L, Chengdu 611130, Sichuan, Peoples R China

来源：

POULTRY SCIENCE | 2024年 / 103卷 / 11期

关键词：

EGCG; OA; hepatic steatosis; lipid deposition; p38 MAPK pathway; REACTIVE OXYGEN; LIVER; MECHANISMS; INFLAMMATION; METABOLISM; EXPRESSION;

D O I：

10.1016/j.psj.2024.104204

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Fatty liver disease in laying hens, characterized by excessive lipid accumulation in hepatocytes, poses significant challenges to poultry health and production efficiency. In this study, we investigated the therapeutic potential of epigallocatechin gallate (EGCG), a bioactive compound found in green tea, in mitigating oleic acid (OA)-induced hepatic steatosis in primary chicken hepatocytes. Treatment with EGCG effectively attenuated lipid deposition by downregulating lipid synthesis- related genes. Moreover, EGCG mitigated oxidative stress, inflammation, DNA damage, and apoptosis induced by OA, thereby preserving hepatocyte viability. Mechanistically, EGCG exerted its protective effects by modulating the p38 MAPK signaling pathway. Our findings suggest that EGCG holds promise as a therapeutic agent for managing fatty liver disease in poultry, offering insights into novel strategies for improving poultry health and production outcomes.

引用

页数：13

共 49 条

[1] Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats [J].