Gut mycobiome alterations and implications for liver diseases

被引：1

作者：

Zeng, Suling ^{[1
]}

Schnabl, Bernd ^{[2
,3
]}

机构：

[1] Hefei Comprehens Natl Sci Ctr, Inst Hlth & Med, Hefei 230601, Peoples R China

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[3] VA San Diego Healthcare Syst, Dept Med, San Diego, CA 92161 USA

来源：

PLOS PATHOGENS | 2024年 / 20卷 / 08期

关键词：

FUNGAL MICROBIOME; PEPTIDE TOXIN; NLRP3; INFLAMMASOME; PROSTAGLANDIN E-2; ACCUMULATION; CANDIDALYSIN; POPULATION; PROMOTE;

D O I：

10.1371/journal.ppat.1012377

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chronic liver disease and its complications are a significant global health burden. Changes in fungal communities (mycobiome), an integral component of the gut microbiome, are associated with and contribute to the development of liver disease. Fungal dysbiosis can induce intestinal barrier dysfunction and allow fungal products to translocate to the liver causing progression of disease. This review explores recent progress in understanding the compositional and functional diversity of gut mycobiome signatures across different liver diseases. It delves into causative connections between gut fungi and liver diseases. We emphasize the significance of fungal translocation, with a particular focus on fungal-derived metabolites and immune cells induced by fungi, as key contributors to liver disease. Furthermore, we review the potential impact of the intrahepatic mycobiome on the progression of liver diseases.

引用

页数：13

共 68 条

[1] Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer [J].

Alam, Aftab ;

Levanduski, Eric ;

Denz, Parker ;

Villavicencio, Helena Solleiro ;

Bhatta, Maulasri ;

Alhorebi, Lamees ;

Zhang, Yali ;

Gomez, Eduardo Cortes ;

Morreale, Brian ;

Senchanthisai, Sharon ;

Li, Jun ;

Turowski, Steven G. ;

Sexton, Sandra ;

Sait, Sheila Jani ;

Singh, Prashant K. ;

Wang, Jianmin ;

Maitra, Anirban ;

Kalinski, Pawel ;

DePinho, Ronald A. ;

Wang, Huamin ;

Liao, Wenting ;

Abrams, Scott I. ;

Segal, Brahm H. ;

Dey, Prasenjit .

CANCER CELL, 2022, 40 (02) :153-+

[2] The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL [J].

Aykut, Berk ;

Pushalkar, Smruti ;

Chen, Ruonan ;

Li, Qianhao ;

Abengozar, Raquel ;

Kim, Jacqueline I. ;

Shadaloey, Sorin A. ;

Wu, Dongling ;

Preiss, Pamela ;

Verma, Narendra ;

Guo, Yuqi ;

Saxena, Anjana ;

Vardhan, Mridula ;

Diskin, Brian ;

Wang, Wei ;

Leinwand, Joshua ;

Kurz, Emma ;

Rossi, Juan A. Kochen ;

Hundeyin, Mautin ;

Zambrinis, Constantinos ;

Li, Xin ;

Saxena, Deepak ;

Miller, George .

NATURE, 2019, 574 (7777) :264-+

[3] Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans [J].

Bacher, Petra ;

Hohnstein, Thordis ;

Beerbaum, Eva ;

Roecker, Marie ;

Blango, Matthew G. ;

Kaufmann, Svenja ;

Roehmel, Jobst ;

Eschenhagen, Patience ;

Grehn, Claudia ;

Seidel, Kathrin ;

Rickerts, Volker ;

Lozza, Laura ;

Stervbo, Ulrik ;

Nienen, Mikalai ;

Babel, Nina ;

Milleck, Julia ;

Assenmacher, Mario ;

Cornely, Oliver A. ;

Ziegler, Maren ;

Wisplinghoff, Hilmar ;

Heine, Guido ;

Worm, Margitta ;

Siegmund, Britta ;

Maul, Jochen ;

Creutz, Petra ;

Tabeling, Christoph ;

Ruwwe-Gloesenkamp, Christoph ;

Sander, Leif E. ;

Knosalla, Christoph ;

Brunke, Sascha ;

Hube, Bernhard ;

Kniemeyer, Olaf ;

Brakhage, Axel A. ;

Schwarz, Carsten ;

Scheffold, Alexander .

CELL, 2019, 176 (06) :1340-+

[4] Fungal dysbiosis in cirrhosis [J].

Bajaj, Jasmohan S. ;

Liu, Eric J. ;

Kheradman, Raffi ;

Fagan, Andrew ;

Heuman, Douglas M. ;

White, Melanie ;

Gavis, Edith A. ;

Hylemon, Phillip ;

Sikaroodi, Masoumeh ;

Gillevet, Patrick M. .

GUT, 2018, 67 (06) :1146-1154

[5] Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells [J].

Benakis, Corinne ;

Brea, David ;

Caballero, Silvia ;

Faraco, Giuseppe ;

Moore, Jamie ;

Murphy, Michelle ;

Sita, Giulia ;

Racchumi, Gianfranco ;

Lingo, Lilan ;

Pamer, Eric G. ;

Iadecola, Costantino ;

Anrather, Josef .

NATURE MEDICINE, 2016, 22 (05) :516-523

[6]

BJORNSSON OG, 1992, J LIPID RES, V33, P1017

[7] Lessons learned from the prenatal microbiome controversy [J].

Blaser, Martin J. ;

Devkota, Suzanne ;

McCoy, Kathy D. ;

Relman, David A. ;

Yassour, Moran ;

Young, Vincent B. .

MICROBIOME, 2021, 9 (01)

[8] Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs [J].

Bradley, C. Pierce ;

Teng, Fei ;

Felix, Krysta M. ;

Sano, Teruyuki ;

Naskar, Debdut ;

Block, Katharine E. ;

Huang, Haochu ;

Knox, Kenneth S. ;

Littman, Dan R. ;

Wu, Hsin-Jung Joyce .

CELL HOST & MICROBE, 2017, 22 (05) :697-+

[9] INHIBITION OF GLUCAGON-STIMULATED CAMP ACCUMULATION AND FATTY-ACID OXIDATION BY E-SERIES PROSTAGLANDINS IN ISOLATED RAT HEPATOCYTES [J].

BRASS, EP ;

ALFORD, CE ;

GARRITY, MJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 930 (01) :122-126

[10] Bacteria may be in the liver, but the jury is still out COMMENT [J].

Broderick, Nichole A. ;

Nagy, Laszlo .

JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 (08)

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