Novel electrochemical sensing platform based on zinc metal organic frameworks/carbon nanofiber nanocomposite for detection of creatinine in human urine

A biomarker known as creatinine is a very important determinant of kidney failure. Creatinine concentrations in blood and urine can identify renal insufficiencies and muscle diseases. Monitoring the creatinine level and quick sensing requires a rapid, robust and simple method for determining the creatinine in human body. To overcome the universal challenge postured by this waste product of muscle, this study presents a novel strategy to fabricate an electrochemical sensor based on zinc MOFs, synthesized using terephthalic di- hydrazide (TPDD) as the organic ligand using a one-pot solvothermal method in the presence of carbon nanofiber matrix for enzyme less sensing the creatinine. The Zn-TPDD/CNF nanocomposite was well characterized by XRD, TGA, BET, XPS, FESEM, CV, DPV, and Raman spectroscopic techniques. Notably, this MOF anchored electrode owns important fundamental features such as large electro active exterior area, plentiful active sites, an immense operational linear range (5 to 250 mu M), a nominal detection limit (10.04 nM), and an outstanding sensitivity towards creatinine. This Zn-TPDD/CNF/GCE electrode not only showcased more extraordinary electrochemical attributes, but its anti-interference stability, flexibility, reproducibility, storage stability, selectivity, and low detection threshold emphasize its ability for real-world applications with reasonable recoveries. Therefore, this modified electrode could be a potential tool for operative creatinine detection in urine.