New Onset of Neuro-Sjögren's Syndrome Nine Months After the Third COVID-19 Vaccine Dose: A Case Report

Sj & ouml;gren's syndrome (SS) is an autoimmune chronic inflammatory disease causing peripheral nerve system and central nervous system issues. It results from lymphocytic infiltrates in exocrine glands, coexists with rheumatoid arthritis, and manifests independently. The COVID-19 vaccine has been linked to increased autoimmune diseases and rheumatological flare-ups, possibly due to its use of adjuvants and molecular mimicry, particularly those containing aluminum. Additionally, SS-like manifestations have been reported after the infection or vaccination, potentially leading to long-term salivary secretory dysfunction. Multiple studies have suggested the presence of a special relationship between COVID-19 vaccination/infection and the emergence of autoimmune syndromes as a negative side effect of the vaccine or direct complication from infection. The time frame for the appearance of the symptoms after vaccination or disease is not well established. Some studies suggested increased risk shortly after vaccination, while others suggested a longterm association. In this case, report, and review article, we discuss the presence of a possible association with the emergence of neuro-SS in a young lady nine months after she received her third dose of COVID-19 vaccination. Furthermore, we reviewed studies highlighting the special link and relationship between the COVID-19 vaccine/infection and SS.