Anti-inflammatory 3,4-seco-triterpenoids from Ganoderma cochlear

被引：1

作者：

Li, Zhi-Yuan ^{[1
,2
]}

Zhang, Jian-Biao ^{[1
,2
]}

Cheng, Yong-Xian ^{[1
,2
,3
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China

[2] Shenzhen Univ, Inst Inheritance Based Innovat Chinese Med, Med Sch,Marshall Lab Biomed Engn, Sch Pharm,Guangdong Prov Key Lab Chinese Med Ingre, Shenzhen 518060, Peoples R China

[3] Hanshan Normal Univ, Sch Life Sci & Food Engn, Guangdong Key Lab Funct Subst Med Edible Resources, Chaozhou 521041, Peoples R China

来源：

TETRAHEDRON | 2024年 / 167卷

基金：

中国国家自然科学基金;

关键词：

Ganoderma cochlear; Triterpenoids; Ganocochnoids A -E; Anti-inflammatory activity; X-ray crystallography; TRITERPENOIDS; LUCIDUM;

D O I：

10.1016/j.tet.2024.134240

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five new 3,4-seco-lanostane triterpenoids, named ganocochnoids A-E (1-5), along with three known analogues (6-8), were isolated from Ganoderma cochlear. The structures of these new compounds, including their absolute configurations, were characterized by 1D and 2D nuclear magnetic resonance (NMR), computational methods, and HRESIMS. In particular, the structure of compound 1 was confirmed through X-ray crystallographic analysis. The anti-inflammatory activity of all the compounds was evaluated in LPS-induced RAW264.7 cells. The Western blot assay indicated that compounds 4 and 5 were found to have inhibitory effects on iNOS protein expression as well as on mRNA levels of TNF-a, Il-1b, and Il-6, and compound 4 also reduced COX-2 protein expression in LPSinduced RAW264.7 cells.

引用

页数：8

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