Percutaneous LAAO and Pulsed-Field Isolation in a Canine Model Feasibility and Safety Evaluation

被引：1

作者：

Yu, Fengyuan ^{[1
]}

Dong, Xiaonan ^{[1
]}

Sun, Yang ^{[2
]}

Reddy, Vivek ^{[3
]}

Sievert, Horst ^{[4
]}

Tang, Min ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Arrhythmia,State Key Lab Cardiovasc Dis, Beijing, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, Dept Pathol,Diagnost Lab Serv, Beijing, Peoples R China

[3] Mt Sinai Hosp, Icahn Sch Med, New York, NY USA

[4] Cardiovasc Ctr Frankfurt, Frankfurt, Germany

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2024年 / 9卷 / 08期

关键词：

atrial fi brillation; left atrial appendage electrical isolation; left atrial appendage occlusion; lesion durability; pulsed fi eld ablation; LEFT ATRIAL APPENDAGE; MITRAL ISTHMUS; ABLATION; FIBRILLATION; OCCLUSION; THROMBUS;

D O I：

10.1016/j.jacbts.2024.05.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this study, we investigated the feasibility, safety, and efficiency of using a novel device system to perform percutaneous left atrial appendage occlusion concomitant with left atrial appendage electrical isolation (LAAEI) via pulsed field ablation. In the acute phase, LAAEI was successful in 10 of 10 canines. At follow-up, full endothelialization was observed in 5 of 5 (100%) cases at 6 months. LAAEI was durable in 8 of 10 (80.00%) canines. Histologic examination in 4 of 6 LAAs with durable isolation showed transmural scars comprising fibrosis and fat. No pericardial effusion or phrenic paralysis was observed at follow-up. This preliminary study provides the scientific basis for first-in-human studies. (JACC Basic Transl Sci 2024;9:971-981) (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：971 / 981

页数：11

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