Percutaneous LAAO and Pulsed-Field Isolation in a Canine Model Feasibility and Safety Evaluation

被引：1

作者：

Yu, Fengyuan ^{[1
]}

Dong, Xiaonan ^{[1
]}

Sun, Yang ^{[2
]}

Reddy, Vivek ^{[3
]}

Sievert, Horst ^{[4
]}

Tang, Min ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Arrhythmia,State Key Lab Cardiovasc Dis, Beijing, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, Dept Pathol,Diagnost Lab Serv, Beijing, Peoples R China

[3] Mt Sinai Hosp, Icahn Sch Med, New York, NY USA

[4] Cardiovasc Ctr Frankfurt, Frankfurt, Germany

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2024年 / 9卷 / 08期

关键词：

atrial fi brillation; left atrial appendage electrical isolation; left atrial appendage occlusion; lesion durability; pulsed fi eld ablation; LEFT ATRIAL APPENDAGE; MITRAL ISTHMUS; ABLATION; FIBRILLATION; OCCLUSION; THROMBUS;

D O I：

10.1016/j.jacbts.2024.05.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this study, we investigated the feasibility, safety, and efficiency of using a novel device system to perform percutaneous left atrial appendage occlusion concomitant with left atrial appendage electrical isolation (LAAEI) via pulsed field ablation. In the acute phase, LAAEI was successful in 10 of 10 canines. At follow-up, full endothelialization was observed in 5 of 5 (100%) cases at 6 months. LAAEI was durable in 8 of 10 (80.00%) canines. Histologic examination in 4 of 6 LAAs with durable isolation showed transmural scars comprising fibrosis and fat. No pericardial effusion or phrenic paralysis was observed at follow-up. This preliminary study provides the scientific basis for first-in-human studies. (JACC Basic Transl Sci 2024;9:971-981) (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：971 / 981

页数：11

共 50 条

[21] Single-center initial experience with a new pulsed-field ablation system: pulmonary vein isolation lesions and beyond [J].

Tsiachris, Dimitrios ;

Antoniou, Christos-Konstantinos ;

Doundoulakis, Ioannis ;

Kordalis, Athanasios ;

Stefanadis, Christodoulos ;

Tsioufis, Konstantinos .

FUTURE CARDIOLOGY, 2024, 20 (14) :739-746

[22] Focal Pulsed Field Ablation for Pulmonary Vein Isolation and Linear Atrial Lesions A Preclinical Assessment of Safety and Durability [J].

Koruth, Jacob S. ;

Kuroki, Kenji ;

Kawamura, Iwanari ;

Stoffregen, William C. ;

Dukkipati, Srinivas R. ;

Neuzil, Petr ;

Reddy, Vivek Y. .

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2020, 13 (06) :E008716

[23] Quantitative assessment of transient autonomic modulation after single-shot pulmonary vein isolation with pulsed-field ablation [J].

Del Monte, Alvise ;

Fernandez, Maria Cespon ;

Vetta, Giampaolo ;

Della Rocca, Domenico Giovanni ;

Pannone, Luigi ;

Mouram, Sahar ;

Sorgente, Antonio ;

Bala, Gezim ;

Stroker, Erwin ;

Sieira, Juan ;

Almorad, Alexandre ;

Sarkozy, Andrea ;

Chierchia, Gian-Battista ;

de Asmundis, Carlo .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2023, 34 (11) :2393-2397

[24] Durability of Pulmonary Vein Isolation Using Pulsed-Field Ablation Results From the Multicenter EU-PORIA Registry [J].

Kueffer, Thomas ;

Bordignon, Stefano ;

Neven, Kars ;

Blaauw, Yuri ;

Hansen, Jim ;

Adelino, Raquel ;

Ouss, Alexandre ;

Fueting, Anna ;

Roten, Laurent ;

Mulder, Bart A. ;

Ruwald, Martin H. ;

Mene, Roberto ;

van der Voort, Pepijn ;

Reinsch, Nico ;

Boveda, Serge ;

Albrecht, Elizabeth M. ;

Schneider, Christopher W. ;

Chun, K. R. Julian ;

Schmidt, Boris ;

Reichlin, Tobias .

JACC-CLINICAL ELECTROPHYSIOLOGY, 2024, 10 (04) :698-708

[25] Impact of a standardized pacing protocol on end point verification and first pass isolation using a multipolar pulsed-field ablation catheter for pulmonary vein isolation [J].

Badertscher, Patrick ;

Weidlich, Simon ;

Stauffer, Niklas ;

Krisai, Philipp ;

Voellmin, Gian ;

Osswald, Stefan ;

Knecht, Sven ;

Sticherling, Christian .

HEART RHYTHM, 2023, 20 (08) :1208-1209

[26] Efficacy and safety of pulsed-field versus conventional thermal ablation for atrial fibrillation: A systematic review and meta-analysis [J].

Amin, Ahmed Mazen ;

Nazir, Abubakar ;

Abuelazm, Mohamed T. ;

Ibrahim, Ahmed A. ;

Elbenawi, Hossam ;

Aboutaleb, Aya ;

Ellabban, Mohamed ;

Arnaout, Moumen ;

Turkmani, Mustafa ;

Abdelazeem, Basel ;

Volgman, Annabelle S. .

JOURNAL OF ARRHYTHMIA, 2024, 40 (05) :1059-1074

[27] Lesion effects in terms of local impedance variations after pulsed-field ablation during pulmonary vein isolation: a case report [J].

Iacopino, Saverio ;

Fabiano, Gennaro ;

Malacrida, Maurizio ;

Petretta, Andrea .

EUROPEAN HEART JOURNAL-CASE REPORTS, 2023, 7 (05)

[28] Repeat pulmonary vein isolation and anterior line ablation using a novel point-by-point pulsed-field ablation system [J].

Wenzel, Jan-Per ;

Lemoine, Marc D. ;

Rottner, Laura ;

My, Ilaria ;

Moser, Fabian ;

Obergassel, Julius ;

Nies, Moritz ;

Riess, Jan ;

Ismaili, Djemail ;

Nikorowitsch, Julius ;

Ouyang, Feifan ;

Kirchhof, Paulus ;

Rillig, Andreas ;

Metzner, Andreas ;

Reissmann, Bruno .

HEART RHYTHM, 2024, 21 (03) :250-257

[29] Safety and chronic lesion characterization of pulsed field ablation in a Porcine model [J].

Stewart, Mark T. ;

Haines, David E. ;

Kos, Bor ;

Kirchhof, Nicole ;

Barka, Noah ;

Mattison, Lars ;

Martien, Matt ;

Onal, Birce ;

Howard, Brian ;

Verma, Atul .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2021, 32 (04) :958-969

[30] Pulsed-Field Ablation on Mitral Isthmus in Persistent Atrial Fibrillation Preliminary Data on Efficacy and Safety [J].

Davong, Baptiste ;

Adelino, Raquel ;

Delasnerie, Hubert ;

Albenque, Jean-Paul ;

Combes, Nicolas ;

Cardin, Christelle ;

Voglimacci-Stephanopoli, Quentin ;

Combes, Stephane ;

Boveda, Serge .

JACC-CLINICAL ELECTROPHYSIOLOGY, 2023, 9 (07) :1070-1081

← 1 2 3 4 5 →