Interplay Effect in Spot-Scanning Proton Therapy with Rescanning, Breath Holding, and Gating: A Phantom Study

被引:1
作者
Belikhin, Mikhail [1 ,2 ]
Shemyakov, Alexander [1 ]
Ivanov, Dmitry [1 ]
Zavestovskaya, Irina [1 ,2 ]
机构
[1] Russian Acad Sci, PN Lebedev Phys Inst, Leninsky Prospekt 53, Moscow 119991, Russia
[2] Kurchatov Inst, Natl Res Ctr, Akad Kurchatova Pl 1, Moscow 123182, Russia
来源
APPLIED SCIENCES-BASEL | 2024年 / 14卷 / 18期
关键词
interplay effect; spot-scanning proton therapy; 4D motion phantom; intrafractional target motion; motion mitigation; DOSIMETRIC EVALUATION; RESPIRATORY MOTION; DOSE HOMOGENEITY; BEAM; CANCER; REPRODUCIBILITY; MITIGATION; RADIOTHERAPY; RADIATION; PHOTON;
D O I
10.3390/app14188473
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The interplay effect is a challenge when using proton scanning beams for the treatment of thoracic and abdominal cancers. The aim of this study was to evaluate the facility-specific interplay effect in terms of dose distortion and irradiation time for different beam delivery modalities, including free breathing (FB) irradiation, rescanning, deep inspiration breath-hold (DIBH), and respiratory gating. This study was carried out at a synchrotron-based facility with spot-scanning beam delivery. A motion phantom with a radiochromic film was used to measure dose distributions. Regular and irregular motion patterns were studied. Dose homogeneity and the gamma index were calculated to quantify the interplay effect. The interplay effect significantly decreased the homogeneity and gamma passing rate by 12% and 46%, respectively, when FB irradiation without motion mitigation was used for 20 mm peak-to-peak motion. Rescanning and DIBH partially mitigated the distortions but doubled the irradiation time, while gating provided the superior dose distribution with only a 25% increase in time compared to FB irradiation without mitigation. The interplay effect was a function of motion amplitude and varied with the beam delivery modality. Gating may be a more preferable technique for the synchrotron-based facility in terms of minimizing dose distortion and treatment time.
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页数:18
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