SARS-CoV-2 humoral immunity in people living with HIV-1

被引：2

作者：

Motsoeneng, Boitumelo M. ^{[1
,2
]}

Bhiman, Jinal N. ^{[1
,2
]}

Richardson, Simone I. ^{[1
,2
]}

Moore, Penny L. ^{[1
,2
,3
]}

机构：

[1] Univ Witwatersrand, Fac Hlth Sci, South African Med Res Council, Antibody Immun Res Unit, Johannesburg, South Africa

[2] Natl Inst Communicable Dis, Ctr HIV & STIs, HIV Virol Sect, Natl Hlth Lab Serv, Johannesburg, South Africa

[3] Univ KwaZulu Natal, Ctr AIDS Program Res South Africa CAPRISA, Durban, South Africa

来源：

TRENDS IN IMMUNOLOGY | 2024年 / 45卷 / 07期

基金：

英国惠康基金; 英国医学研究理事会; 新加坡国家研究基金会;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; FC EFFECTOR FUNCTIONS; NEUTRALIZING ANTIBODIES; COVID-19; DEATH; DISEASE; VACCINE; IMMUNOGENICITY; INFECTION; COHORT; VARIANTS;

D O I：

10.1016/j.it.2024.05.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of COVID-19 on the high number of immunocompromised people living with HIV-1 (PLWH), particularly in Africa, remains a critical concern. Here, we identify key areas that still require further investigation, by examining COVID-19 vaccine effectiveness, and understanding antibody responses in SARS-CoV-2 infection and vaccination in comparison with people without HIV-1 (PWOH). We also assess the potential impact of pre-existing immunity against endemic human coronaviruses on SARS-CoV-2 responses in these individuals. Lastly, we discuss the consequences of persistent infection in PLWH (or other immunocompromised individuals), including prolonged shedding, increased viral diversity within the host, and the implications on SARS-CoV-2 evolution in Africa.

引用

页码：511 / 522

页数：12

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