Synthesis of Diverse Ureas from Amines and CO2 at Atmospheric Pressure and Room Temperature

被引：0

作者：

Gou, Wenchang ^{[1
]}

Dai, Pinli ^{[1
]}

Wang, Mei ^{[1
]}

Wang, Yunhuan ^{[1
]}

Ma, Nana ^{[1
]}

Zhou, Xuan ^{[1
]}

Xu, Yingjian ^{[2
]}

Zhang, Lin ^{[1
]}

Li, Chun ^{[1
]}

机构：

[1] Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550004, Peoples R China

[2] GoldenKeys High tech Mat Co Ltd, Guiyang 550025, Guizhou, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 17期

基金：

中国国家自然科学基金;

关键词：

CARBON-DIOXIDE; EFFICIENT SYNTHESIS; UNSYMMETRICAL UREAS; DERIVATIVES; DISCOVERY; CATALYST; BENZIMIDAZOLONES; CARBONYLATION; CYCLIZATION; PENCYCURON;

D O I：

10.1021/acs.joc.4c01474

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free method is developed to perform the synthesis of urea derivatives utilizing CO2 as the C1 building block at atmospheric pressure and room temperature. In addition to diverse symmetric and dissymmetric ureas, benzimidazolones and quinazolinone can also be easily prepared using this protocol. Most importantly, the gram-scale preparation of fungicide pencycuron and antipsychotic drug pimavanserin proceeded smoothly under the mild conditions.

引用

页码：12498 / 12507

页数：10

共 73 条

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