Molecularly Imprinted Polypyrrole-Modified Screen-Printed Electrode for Dopamine Determination

被引：6

作者：

Merli, Daniele ^{[1
]}

Cutaia, Alessandra ^{[1
]}

Hallulli, Ines ^{[1
]}

Bonanni, Alessandra ^{[1
]}

Alberti, Giancarla ^{[1
]}

机构：

[1] Univ Pavia, Dept Chem, Via Taramelli 12, I-27100 Pavia, Italy

来源：

POLYMERS | 2024年 / 16卷 / 17期

关键词：

dopamine; molecularly imprinted polymers; electropolymerized molecularly imprinted polypyrrole; polypyrrole-based sensors; screen-printed electrodes; differential pulse voltammetry; METAL-ORGANIC XEROGELS; CHEMILUMINESCENCE DETECTION; VOLTAMMETRIC DETERMINATION; CAPILLARY-ELECTROPHORESIS; ELECTROCHEMICAL SENSOR; URINE SAMPLES; POLYMERS; EPINEPHRINE; CATECHOLAMINES; POLYMORPHISM;

D O I：

10.3390/polym16172528

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This paper introduces a quantitative method for dopamine determination. The method is based on a molecularly imprinted polypyrrole (e-MIP)-modified screen-printed electrode, with differential pulse voltammetry (DPV) as the chosen measurement technique. The dopamine molecules are efficiently entrapped in the polymeric film, creating recognition cavities. A comparison with bare and non-imprinted polypyrrole-modified electrodes clearly demonstrates the superior sensitivity, selectivity, and reproducibility of the e-MIP-based one; indeed, a sensitivity of 0.078 mu A mu M-1, a detection limit (LOD) of 0.8 mu M, a linear range between 0.8 and 45 mu M and a dynamic range of up to 350 mu M are achieved. The method was successfully tested on fortified synthetic and human urine samples to underline its applicability as a screening method for biomedical tests.

引用

页数：19

共 80 条

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