Impact of frailty on adverse outcomes in patients with abdominal aortic aneurysm undergoing surgery: a systematic review and meta-analysis

被引:2
作者
Zhang, Junfang [1 ]
Qiu, Yue [2 ]
Zhang, Heng [3 ]
Fan, Yu [2 ]
机构
[1] Southeast Univ, Nanjing Lishui Dist Peoples Hosp, Zhongda Hosp, Lishui Branch,Dept Med Nutr, Nanjing 211200, Peoples R China
[2] Jiangsu Univ, Affiliated Peoples Hosp, Inst Mol Biol & Translat Med, Zhenjiang 212002, Peoples R China
[3] Southeast Univ, Nanjing Lishui Dist Peoples Hosp, Zhongda Hosp, Lishui Branch,Dept Gen Surg, Nanjing 211200, Peoples R China
关键词
Frailty; Abdominal aortic aneurysm; All-Cause mortality; Postoperative complications; Meta-analysis; POSTOPERATIVE COMPLICATIONS; VASCULAR-SURGERY; RISK-FACTORS; REPAIR; MANAGEMENT; MORTALITY; PREDICTOR; MORBIDITY;
D O I
10.1016/j.jnha.2024.100213
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: To explore the prognostic role of frailty in patients with abdominal aortic aneurysm (AAA) by conducting this systematic review and meta-analysis Methods: We conducted an extensive literature search on PubMed, Web of Sciences, and Embase databases to identify studies that reported the association of frailty with postoperative complications, reintervention, or all-cause mortality in patients with AAA after surgery. Short-term mortality was defined by a combination of in-hospital and 30-day death. Results: Seven cohort studies reporting on 9 articles with 323,788 AAA patients were included. The reported prevalence of frailty in AAA patients ranged between 2.3% and 34.6%. Pooling the results revealed that frailty was significantly associated with a higher risk of short-term all-cause mortality (adjusted risk ratios [RR] 3.20; 95% confidence intervals [CI] 1.95-5.26), long-term all-cause mortality (adjusted RR 2.86; 95% CI 2.57-3.17), and postoperative complications (adjusted RR 2.19; 95% CI 1.50-3.20) compared to non-frail individuals. However, there was no clear association between frailty and reintervention (HR 1.44; 95% CI 0.97-2.16). Conclusions: Frailty independently predicts the short and long-term survival as well as postoperative complications in patients with AAA undergoing surgery. Assessing frail status may potentially enhance surgical decision-making for these patients. (c) 2024 The Author(s). Published by Elsevier Masson SAS on behalf of SERDI Publisher. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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页数:7
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