Conservative Treatment in Avascular Necrosis of the Femoral Head: A Systematic Review

被引:5
作者
Goncharov, Evgeniy Nikolaevich [1 ]
Koval, Oleg Aleksandrovich [1 ]
Bezuglov, Eduard Nikolaevich [2 ]
Vetoshkin, Aleksandr Aleksandrovich [3 ]
Goncharov, Nikolay Gavriilovich [4 ]
De Jesus Encarnacion Ramirez, Manuel [5 ]
Montemurro, Nicola [6 ]
机构
[1] Russian Sci Ctr Surg, Moscow 121359, Russia
[2] Sechenov First Moscow State Med Univ, Dept Sports Med & Med Rehabil, Moscow 119435, Russia
[3] Nikiforov Russian Ctr Emergency & Radiat Med, St Petersburg 187015, Russia
[4] Russian Med Acad Continuous Profess Educ, Moscow 119435, Russia
[5] RUDN Univ, Dept Neurosurg, Moscow 121359, Russia
[6] Azienda Osped Univ Pisana AOUP, Dept Neurosurg, I-56100 Pisa, Italy
关键词
avascular necrosis; femoral head; anatomy; conservative treatment; surgery; MESENCHYMAL STEM-CELLS; BONE MORPHOGENETIC PROTEIN-2; ENDOTHELIAL GROWTH-FACTOR; CORE DECOMPRESSION; NONTRAUMATIC OSTEONECROSIS; EXTRACORPOREAL SHOCKWAVE; PERTHES-DISEASE; RABBIT MODEL; THERAPY; REGENERATION;
D O I
10.3390/medsci12030032
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Avascular necrosis (AVN) of the femoral head is a pressing orthopedic issue, leading to bone tissue death due to disrupted blood supply and affecting the quality of life of individuals significantly. This review focuses on conservative treatments, evaluating their efficacy as mainstay therapies. Enhanced understanding of AVN's pathophysiology and advancements in diagnostic tools have rekindled interest in non-surgical interventions, emphasizing personalized, multidisciplinary approaches for improved outcomes. Material and Method: A systematic search was conducted on PubMed, SCOPUS, and Google Scholar databases from January 2020 to August 2023, with the objective of focusing on conservative treatments for AVN of the femoral head. Eligible studies, including original research, case reports, and observational studies, were examined for relevant, well-documented patient outcomes post-conservative treatments, excluding non-English and surgically focused articles without comparative conservative data. Results: A systematic search yielded 376 records on AVN of the femoral head across multiple databases. After de-duplication and rigorous screening for relevance and quality, 11 full-text articles were ultimately included for a comprehensive qualitative synthesis, focusing on conservatively managing the condition. Conclusions: This review evaluates the effectiveness of conservative treatments such as pharmacological interventions and physical modalities in managing AVN of the femoral head. Despite promising results in symptom alleviation and disease progression delay, variability in outcomes and methodological limitations in studies necessitate further rigorous, randomized controlled trials for a robust, patient-centric approach to optimize therapeutic outcomes in AVN management.
引用
收藏
页数:17
相关论文
共 95 条
[1]  
AARON RK, 1989, CLIN ORTHOP RELAT R, P209
[2]   Adipose-derived Stem Cells Enhance Bone Regeneration in Vascular Necrosis of the Femoral Head in the Rabbit [J].
Abudusaimi, A. ;
Aihemaitijiang, Y. ;
Wang, Y-H ;
Cui, L. ;
Maimaitiming, S. ;
Abulikemu, M. .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2011, 39 (05) :1852-1860
[3]   MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications- A systematic review [J].
Agaverdiev, Murad ;
Shamsov, Bedil ;
Mirzoev, Sorbon ;
Vardikyan, Andranik ;
Ramirez, Manuel Encarnacion ;
Nurmukhametov, Renat ;
Beilerli, Aferin ;
Zhang, Bohan ;
Gareev, Ilgiz ;
Pavlov, Valentin .
NON-CODING RNA RESEARCH, 2023, 8 (02) :146-154
[4]   Does Statin Usage Reduce the Risk of Corticosteroid-Related Osteonecrosis in Renal Transplant Population? [J].
Ajmal, Muhammad ;
Matas, A. J. ;
Kuskowski, Michael ;
Cheng, Edward Y. .
ORTHOPEDIC CLINICS OF NORTH AMERICA, 2009, 40 (02) :235-+
[5]   The use of extracorporeal shock waves in the treatment of osteonecrosis of the femoral head: a systematic review [J].
Alves, Eneida Machado ;
Angrisani, Adriano Tanajura ;
Santiago, Mittermayer B. .
CLINICAL RHEUMATOLOGY, 2009, 28 (11) :1247-1251
[6]   Regenerative therapies increase survivorship of avascular necrosis of the femoral head: a systematic review and meta-analysis [J].
Andriolo, Luca ;
Merli, Giulia ;
Tobar, Carlos ;
Altamura, Sante Alessandro ;
Kon, Elizaveta ;
Filardo, Giuseppe .
INTERNATIONAL ORTHOPAEDICS, 2018, 42 (07) :1689-1704
[7]   Cell-Free miRNAs as Non-Invasive Biomarkers in Brain Tumors [J].
Beylerli, Ozal ;
Ramirez, Manuel de Jesus Encarnacion ;
Shumadalova, Alina ;
Ilyasova, Tatiana ;
Zemlyanskiy, Mikhail ;
Beilerli, Aferin ;
Montemurro, Nicola .
DIAGNOSTICS, 2023, 13 (18)
[8]   STRUCTURAL CONSEQUENCES OF SUBCHONDRAL BONE INVOLVEMENT IN SEGMENTAL OSTEONECROSIS OF THE FEMORAL-HEAD [J].
BROWN, TD ;
BAKER, KJ ;
BRAND, RA .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1992, 10 (01) :79-87
[9]  
Callaghan JohnJ., 2007, ADULT HIP
[10]   Deproteinized bone with VEGF gene transfer to facilitate the repair of early avascular necrosis of femoral head of rabbit [J].
Cao Kai ;
Huang Wei ;
An Hong ;
Jiang Dian-ming ;
Shu Yong ;
Han Zhi-min .
CHINESE JOURNAL OF TRAUMATOLOGY, 2009, 12 (05) :269-274