Biomarkers in acute kidney injury

被引：9

作者：

Ostermann, Marlies ^{[1
]}

Legrand, Matthieu ^{[2
]}

Meersch, Melanie ^{[3
]}

Srisawat, Nattachai ^{[4
,5
]}

Zarbock, Alexander ^{[2
,3
]}

Kellum, John A. ^{[6
]}

机构：

[1] Guys & St Thomas NHS Fdn Trust, Dept Crit Care, London SE1 7EH, England

[2] Univ Calif San Francisco, Dept Anesthesia & Perioperat Care, Div Crit Care Med, San Francisco, CA USA

[3] Univ Hosp Munster, Dept Anesthesiol Intens Care & Pain Med, Munster, Germany

[4] Chulalongkorn Univ, Fac Med, Div Nephrol, Dept Med, Bangkok, Thailand

[5] Chulalongkorn Univ, Ctr Excellence Crit Care Nephrol, Bangkok, Thailand

[6] Univ Pittsburgh, Dept Crit Care Med, Pittsburgh, PA USA

来源：

ANNALS OF INTENSIVE CARE | 2024年 / 14卷 / 01期

关键词：

GELATINASE-ASSOCIATED LIPOCALIN; RENAL REPLACEMENT THERAPY; BINDING-PROTEIN; 7; TISSUE INHIBITOR; URINARY; AKI; RECOVERY;

D O I：

10.1186/s13613-024-01360-9

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Acute kidney injury (AKI) is a multifactorial syndrome with a high risk of short- and long-term complications as well as increased health care costs. The traditional biomarkers of AKI, serum creatinine and urine output, have important limitations. The discovery of new functional and damage/stress biomarkers has enabled a more precise delineation of the aetiology, pathophysiology, site, mechanisms, and severity of injury. This has allowed earlier diagnosis, better prognostication, and the identification of AKI sub-phenotypes. In this review, we summarize the roles and challenges of these new biomarkers in clinical practice and research.

引用

页数：12

共 79 条

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