Practical Synthesis of N -Anilinylphenothiazines Using a Cyclic Hypervalent Iodine Coupling Reagent

被引：0

作者：

Yanase, Kana ^{[1
]}

Morimoto, Koji ^{[1
,2
]}

Dohi, Toshifumi ^{[1
,2
]}

Kita, Yasuyuki ^{[2
]}

机构：

[1] Ritsumeikan Univ, Coll Pharmaceut Sci, 1-1-1 Nojihigashi, Kusatsu, Shiga 5258577, Japan

[2] Ritsumeikan Univ, Res Org Sci & Technol, 1-1-1 Nojihigashi, Kusatsu, Shiga 5258577, Japan

来源：

SYNTHESIS-STUTTGART | 2025年 / 57卷 / 04期

关键词：

hypervalent iodine(III) reagent; aryl C-H amination; solid-liquid separation; coupling reaction; N; -anilinylphenothiazines;

D O I：

10.1055/a-2383-0958

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved protocol for the synthesis of N-anilinylphenothiazines based on the coupling reaction of anilines with phenothiazines using cyclic iodine(III) reagent is presented. In the improved method, the product can be isolated and purified without using column chromatography, and the cyclic hypervalent iodine reagent can be quantitatively recovered by aliquot manipulation. The workup procedure presented here is simpler compared to previously reported ones, facilitating large-scale synthesis. The para -selective phenothiazination of nitrogen-containing heterocycles such as hydroquinoline, which is important in pharmacology, was also successfully performed.

引用

页码：748 / 753

页数：6