Amyloid-β-targeting immunotherapies for Alzheimer's disease

被引：12

作者：

Jin, Yi ^{[1
]}

Du, Qiaofei ^{[1
]}

Song, Mingjie ^{[1
]}

Kang, Ruixin ^{[1
]}

Zhou, Jianping ^{[1
]}

Zhang, Huaqing ^{[1
]}

Ding, Yang ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, Nanjing 210009, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2024年 / 375卷

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; beta-amyloid; Monoclonal antibody; A beta vaccine; Immunotherapy; Blood-brain barrier; BLOOD-BRAIN-BARRIER; IRON-OXIDE NANOPARTICLES; ADENOASSOCIATED VIRUS VECTOR; A-BETA; FOCUSED ULTRASOUND; GOLD NANOPARTICLES; TRANSGENIC MICE; DRUG EXPOSURE; PLAQUE BURDEN; GENE DELIVERY;

D O I：

10.1016/j.jconrel.2024.09.012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent advances in clinical passive immunotherapy have provided compelling evidence that eliminating amyloid-beta (A beta) slows cognitive decline in Alzheimer's disease (AD). However, the modest benefits and side effects observed in clinical trials indicate that current immunotherapy therapy is not a panacea, highlighting the need for a deeper understanding of AD mechanisms and the significance of early intervention through optimized immunotherapy or immunoprevention. This review focuses on the centrality of A beta pathology in AD and summarizes recent clinical progress in passive and active immunotherapies targeting A beta, discussing their lessons and failures to inform future anti-A beta biotherapeutics design. Various delivery strategies to optimize A beta-targeting immunotherapies are outlined, highlighting their benefits and drawbacks in overcoming challenges such as poor stability and limited tissue accessibility of anti-A beta biotherapeutics. Additionally, the perspectives and challenges of immunotherapy and immunoprevention targeting A beta are concluded in the end, aiming to guide the development of next-generation anti-A beta immunotherapeutic agents towards improved efficacy and safety.

引用

页码：346 / 365

页数：20

共 206 条

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