The Role and Therapeutic Potential of Pyroptosis in Colorectal Cancer: A Review

被引：4

作者：

Fang, Qing ^{[1
,2
]}

Xu, Yunhua ^{[1
,3
]}

Tan, Xiangwen ^{[1
,4
]}

Wu, Xiaofeng ^{[1
,2
]}

Li, Shuxiang ^{[5
]}

Yuan, Jinyi ^{[5
]}

Chen, Xiguang ^{[5
]}

Huang, Qiulin ^{[5
]}

Fu, Kai ^{[6
,7
]}

Xiao, Shuai ^{[1
,5
]}

机构：

[1] Univ South China, Affiliated Hosp 1, Canc Res Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China

[2] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Clin Lab Med, Hengyang 421001, Peoples R China

[3] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang Med Sch, Hengyang 421001, Peoples R China

[4] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Hepatobiliary Surg, Hengyang 421001, Peoples R China

[5] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Gastrointestinal Surg, Hengyang 421001, Peoples R China

[6] Cent South Univ, Xiangya Hosp, Inst Mol Precis Med, Changsha 410008, Peoples R China

[7] Cent South Univ, Xiangya Hosp, Hunan Key Lab Mol Precis Med, Changsha 410008, Peoples R China

来源：

BIOMOLECULES | 2024年 / 14卷 / 07期

基金：

中国国家自然科学基金;

关键词：

pyroptosis; colorectal cancer; proliferation; growth; therapy; NONCANONICAL INFLAMMASOME ACTIVATION; INDUCED CELL-DEATH; GASDERMIN D; DFNA5; GENE; GASTROINTESTINAL-TRACT; INDUCE PYROPTOSIS; PROTEIN FAMILY; POOR SURVIVAL; TUMOR-GROWTH; EXPRESSION;

D O I：

10.3390/biom14070874

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. The unlimited proliferation of tumor cells is one of the key features resulting in the malignant development and progression of CRC. Consequently, understanding the potential proliferation and growth molecular mechanisms and developing effective therapeutic strategies have become key in CRC treatment. Pyroptosis is an emerging type of regulated cell death (RCD) that has a significant role in cells proliferation and growth. For the last few years, numerous studies have indicated a close correlation between pyroptosis and the occurrence, progression, and treatment of many malignancies, including CRC. The development of effective therapeutic strategies to inhibit tumor growth and proliferation has become a key area in CRC treatment. Thus, this review mainly summarized the different pyroptosis pathways and mechanisms, the anti-tumor (tumor suppressor) and protective roles of pyroptosis in CRC, and the clinical and prognostic value of pyroptosis in CRC, which may contribute to exploring new therapeutic strategies for CRC.

引用

页数：19

共 161 条

[1] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer [J].