Analysis of Single Nucleotide Polymorphisms (SNPs) rs2234693 and rs9340799 of the ESR1 Gene and the Risk of Breast Cancer

被引：1

作者：

Smolarz, Beata ^{[1
]}

Nowak, Anna Zadrozna ^{[2
]}

Brys, Magdalena ^{[3
]}

Forma, Ewa ^{[3
]}

Lukasiewicz, Honorata ^{[4
]}

Samulak, Dariusz ^{[4
,5
]}

Langner, Sara ^{[6
]}

Romanowicz, Hanna ^{[1
]}

机构：

[1] Polish Mothers Mem Hosp Res Inst, Dept Pathol, Lab Canc Genet, Lodz, Poland

[2] Med Univ Lodz, Copernicus Mem Hosp, Dept Chemotherapy, Lodz, Poland

[3] Univ Lodz, Fac Biol & Environm Protect, Dept Cytobiochem, Lodz, Poland

[4] Reg Hosp Kalisz, Dept Obstet & Gynecol & Gynecol Oncol, Kalisz, Poland

[5] President Stanislawlaw Wojciechowski Calisia Acad, Dept Obstet, Kalisz, Poland

[6] Med Univ Gdansk, Gdansk, Poland

来源：

IN VIVO | 2024年 / 38卷 / 05期

关键词：

ESR1; polymorphism; rs2234693; rs9340799; breast; ESTROGEN-RECEPTOR-ALPHA; ESR1; GENE; XBAI POLYMORPHISMS; ASSOCIATION; WOMEN; PVUII; SUSCEPTIBILITY; TARGET;

D O I：

10.21873/invivo.13676

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: The aim of this study was to analyze rs2234693 and rs9340799 polymorphisms of the ESR1 gene in the context of breast cancer risk in Polish patients. Materials and Methods: The study involved a group of 117 patients with breast cancer and 106 controls. The analyses were carried out using the polymerase chain technique. Results: The presence of the CC genotype in rs2234693 more than doubled the risk of breast cancer (p=0.04), whereas the presence of the TT genotype in rs2234693 significantly reduced the risk of developing this type of cancer (p=0.0002). The presence of the GG genotype in rs9340799 more than doubled the risk of breast cancer (p=0.04), which was confirmed by the analysis of the recessive model (p=0.04). Conclusion: The polymorphisms rs2234693 and rs9340799 of the ESR1 gene may be associated with the risk of breast cancer among Polish women.

引用

页码：2134 / 2143

页数：10

共 40 条

[1] Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico
Angel Cahua-Pablo, Jose
Cruz, Miguel
Mendez-Palacios, Abigail
Lizzete Antunez-Ortiz, Diana
Vences-Velazquez, Amalia
del Carmen Alarcon-Romero, Luz
Parra, Esteban Juan
Argelia Tello-Flores, Vianet
Antonio Leyva-Vazquez, Marco
Valladares-Salgado, Adan
Paola Perez-Macedonio, Claudia
Flores-Alfaro, Eugenia
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (09) : 21539 - 21554
[2] Estrogen receptor α and β profiling in human breast cancer
Balfe, P
McCann, A
McGoldrick, A
McAllister, K
Kennedy, M
Dervan, P
Kerin, MJ
[J]. EJSO, 2004, 30 (05): : 469 - 474
[3] The impact of xenoestrogens on effectiveness of treatment for hormone-dependent breast cancer - current state of knowledge and perspectives for research
Boszkiewicz, Kamila
Sawicka, Ewa
Piwowar, Agnieszka
[J]. ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE, 2020, 27 (04) : 526 - 534
[4] Menopausal Hormone Therapy and Breast Cancer
Chlebowski, Rowan T.
Manson, JoAnn E.
[J]. CANCER JOURNAL, 2022, 28 (03) : 169 - 175
[5] Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women
Dai, Zhijun
Tian, Tian
Wang, Meng
Yang, Tielin
Li, Hongtao
Lin, Shuai
Hao, Qian
Xu, Peng
Deng, Yujiao
Zhou, Linghui
Li, Na
Diao, Yan
[J]. CANCER CELL INTERNATIONAL, 2019, 19 (1)
[6] Dorgan JF, 2002, JNCI-J NATL CANCER I, V94, P606
[7] Dunning AM, 1999, CANCER EPIDEM BIOMAR, V8, P843
[8] Hormone-Dependent Cancers: Molecular Mechanisms and Therapeutical Implications
Emons, Guenter
[J]. CELLS, 2023, 12 (01)
[9] Sex Hormone-regulated CMG2 Is Involved in Breast and Prostate Cancer Progression
Fang, Ziqian
Killick, Charlotte
Halfpenny, Cerith
Frewer, Natasha
Frewer, Kathryn A.
Ruge, Fiona
Jiang, Wen G.
Ye, Lin
[J]. CANCER GENOMICS & PROTEOMICS, 2022, 19 (06) : 703 - 710
[10] Mechanisms for estrogen receptor expression in human cancer
Hua, Hui
Zhang, Hongying
Kong, Qingbin
Jiang, Yangfu
[J]. EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2018, 7

← 1 2 3 4 →