This study aimed to synthesize a hyperbranched poly(amidoamine) dendrimer (PAMAMD) and its ZnOnanohybrid (PAMAMD-Zn). The synthesized products were characterized using various techniques; XRD, DLS, SEM and FT-IR. Subsequently, the synthesized products were tested for their broad-spectrum antimicrobial activities. Additionally, they were evaluated for their suitability as biocides and corrosion inhibitors against aerobic and anaerobic corrosive bacteria which isolated from an Egyptian petroleum company's environment. The results were notably intriguing as both the synthesized products, PAMAMD and PAMAMD-Zn, demonstrated a broad-spectrum antimicrobial activity against various standard microbial strains. Furthermore, the PAMAMD-Zn exhibited a higher broad-spectrum antimicrobial activity with the lowest minimum inhibitory concentration (MIC), minimum bactericidal and fungicidal concentration (MBC, MFC) values compared to the PAMAMD. In addition, both products exhibited metal corrosion inhibition efficiencies against aerobic corrosive communities of 92.1 and 94.4%, respectively and anaerobic corrosive communities of 91.6 and 96.3%, respectively.