Effects of integrated traditional Chinese and Western medicine for acute pancreatitis: A real-world study in a tertiary teaching hospital

被引：3

作者：

Deng, Lihui ^{[1
,2
]}

Chen, Zhiyao ^{[1
]}

Zhu, Ping ^{[1
]}

Hu, Cheng ^{[1
]}

Jin, Tao ^{[1
]}

Wang, Xinwei ^{[1
]}

Li, Lan ^{[1
]}

Lin, Ziqi ^{[1
]}

Guo, Jia ^{[1
]}

Yang, Xiaonan ^{[1
]}

Shi, Na ^{[1
]}

Zhang, Xiaoxin ^{[1
]}

Yang, Xinmin ^{[1
]}

Jiang, Kun ^{[1
]}

Ma, Yun ^{[1
]}

Tan, Qingyuan ^{[1
]}

Li, Ling ^{[3
,4
,5
]}

Wang, Wen ^{[3
,4
,5
]}

Huang, Wei ^{[1
,2
]}

Sun, Xin ^{[2
,3
,4
,5
]}

Xia, Qing ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, Inst Integrated Tradit Chinese & Western Med, West China Ctr Excellence Pancreatitis, Chengdu, Peoples R China

[2] Sichuan Univ, West China Hosp, Res Inst Integrated Tradit Chinese & Western Med, Chengdu, Peoples R China

[3] Sichuan Univ, West China Hosp, Inst Integrated Tradit Chinese & Western Med, Chinese Evidence Based Med & Cochrane China Ctr, Chengdu, Peoples R China

[4] Natl Med Prod Adm Key Lab Real World Data Res & Ev, Chengdu, Peoples R China

[5] Sichuan Ctr Technol Innovat Real World Data, Chengdu, Peoples R China

来源：

JOURNAL OF EVIDENCE BASED MEDICINE | 2024年 / 17卷 / 03期

基金：

中国国家自然科学基金;

关键词：

acute pancreatitis; heat-disease theory; integrated traditional Chinese and Western medicine; real-world study; Western medicine; ATLANTA CLASSIFICATION; PROPENSITY SCORE; GLOBAL INCIDENCE; MORTALITY; MANAGEMENT; GUIDELINE;

D O I：

10.1111/jebm.12635

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: This study aimed to evaluate whether integrated traditional Chinese medicine (TCM) and Western medicine (WM) is more effective than WM for acute pancreatitis (AP). Methods: Patients with AP were enrolled and divided into the TCM and WM (TCM&WM) and WM groups according to the therapeutic protocol in real clinical settings. We applied 1:3 propensity score matching, which was to adjust confounding factors. The primary outcome was mortality, whereas the secondary outcomes were organ failure, organ supportive therapies, local complications, hospitalization cost, and length of hospital stay. Sensitivity and subgroup analyses were also performed. Results: Of 5442 patients with AP, 4691 and 751 were included in the TCM&WM and WM groups, respectively. After PSM, patient baseline characteristics were well balanced. Compared with the WM group (n n = 734), the TCM&WM group (n n = 2096) had lower overall mortality rate (1.7% vs. 3.4%; risk ratio, 0.482; 95% confidence interval, 0.286-0.810; p = 0.005). The TCM&WM group was associated with lower risk of persistent renal failure, multiple organ failure, and infection, lower utilization of organ supportive therapies, shortened lengths of hospital and intensive care unit stay, and lower hospital costs. Sensitivity analyses showed similar results. Subgroup analysis favored TCM&WM treatment for patients aged < 60 years, with hypertriglyceridic etiology, and with admission interval between 24 and 48 h. Conclusion: TCM&WM treatment can achieve lower risks of mortality and organ failure and better economic effectiveness in patients with AP than WM treatment. This study provides a promising alternative of TCM&WM treatment for AP in the real-world setting.

引用

页码：575 / 587

页数：13