Innovations in Biosensor Technologies for Healthcare Diagnostics and Therapeutic Drug Monitoring: Applications, Recent Progress, and Future Research Challenges

被引：42

作者：

Hemdan, Mohamed ^{[1
]}

Ali, Mohamed A. ^{[1
]}

Doghish, Ahmed S. ^{[2
,3
]}

Mageed, Sherif S. Abdel ^{[4
]}

Elazab, Ibrahim M. ^{[5
]}

Khalil, Magdy M. ^{[6
,7
]}

Mabrouk, Mostafa ^{[8
]}

Das, Diganta B. ^{[9
]}

Amin, Alaa S. ^{[10
]}

机构：

[1] Badr Univ Cairo BUC, Sch Biotechnol, Badr City 11829, Egypt

[2] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Badr City 11829, Egypt

[3] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Nasr City 11231, Egypt

[4] Badr Univ Cairo BUC, Fac Pharm, Pharmacol & Toxicol Dept, Badr City 11829, Egypt

[5] Tanta Univ, Fac Pharm, Dept Biochem, Tanta 31527, Egypt

[6] Helwan Univ, Fac Sci, Dept Phys, Med Biophys, Cairo 11795, Egypt

[7] Badr Univ Cairo BUC, Sch Appl Hlth Sci, Badr City 11829, Egypt

[8] Natl Res Ctr, Dept Refractories Ceram & Bldg Mat, 33 El Bohouth St, Giza 12622, Egypt

[9] Loughborough Univ, Dept Chem Engn, Loughborough LE11 3TU, England

[10] Benha Univ, Fac Sci, Chem Dept, Banha 13511, Egypt

来源：

SENSORS | 2024年 / 24卷 / 16期

关键词：

biosensors; healthcare applications; disease biomarker detection; therapeutic drug monitoring; nanotechnology integration; MANAGEMENT; RESISTANCE; PROTEIN; PERSPECTIVES; MECHANISMS; WARFARIN; RANGE;

D O I：

10.3390/s24165143

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This comprehensive review delves into the forefront of biosensor technologies and their critical roles in disease biomarker detection and therapeutic drug monitoring. It provides an in-depth analysis of various biosensor types and applications, including enzymatic sensors, immunosensors, and DNA sensors, elucidating their mechanisms and specific healthcare applications. The review highlights recent innovations such as integrating nanotechnology, developing wearable devices, and trends in miniaturisation, showcasing their transformative potential in healthcare. In addition, it addresses significant sensitivity, specificity, reproducibility, and data security challenges, proposing strategic solutions to overcome these obstacles. It is envisaged that it will inform strategic decision-making, drive technological innovation, and enhance global healthcare outcomes by synthesising multidisciplinary insights.

引用

页数：28

共 205 条

[1] Development of the DNA-based voltammetric biosensor for detection of vincristine as anticancer drug [J].