Aggregation-induced emission: Application in diagnosis and therapy of hepatocellular carcinoma

被引：0
作者：
Xu, Wenjing [1 ,3 ,4 ,5 ,6 ,7 ]
Jian, Danfeng [2 ]
Yang, Huang [1 ,3 ,4 ,5 ,6 ,7 ,8 ]
Wang, Weili [1 ,3 ,4 ,5 ,6 ,7 ]
Ding, Yuan [1 ,3 ,4 ,5 ,6 ,7 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Hepatobiliary & Pancreat Surg, Hangzhou 310009, Peoples R China
[2] Zhejiang Sci Tech Univ, MOE Key Lab Adv Text Mat & Mfg Technol, Hangzhou 310018, Peoples R China
[3] Zhejiang Univ, Key Lab Precis Diag & Treatment Hepatobiliary & Pa, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China
[4] Zhejiang Univ, Affiliated Hosp 2, Res Ctr Diag & Treatment Technol Hepatocellular Ca, Hangzhou 310009, Zhejiang, Peoples R China
[5] Zhejiang Univ, Clin Med Innovat Ctr Precis Diag & Treatment Hepat, Hangzhou 310009, Zhejiang, Peoples R China
[6] Zhejiang Univ, Affiliated Hosp 2, Clin Res Ctr Hepatobiliary & Pancreat Dis Zhejiang, Hangzhou 310009, Zhejiang, Peoples R China
[7] Zhejiang Univ, Canc Ctr, Hangzhou 310009, Zhejiang, Peoples R China
[8] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
来源：
BIOSENSORS & BIOELECTRONICS | 2024年 / 266卷
关键词：
Aggregation-induced emission; Hepatocellular carcinoma; Multimodal imaging; Accurate diagnosis and therapy; Phototherapy; FLUORESCENT-PROBE; INDOCYANINE GREEN; LIPID DROPLETS; GUIDED SURGERY; NANOPARTICLES; CELLS; CARBOXYLESTERASE; PHOTOSENSITIZERS; RESTRICTION; ENHANCEMENT;
D O I：
10.1016/j.bios.2024.116722
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Hepatocellular carcinoma (HCC) is a serious health issue due to its low early diagnosis rate, resistance to chemotherapy, and poor five-year survival rate. Therefore, it is crucial to explore novel diagnostic and therapeutic approaches tailored to the characteristics of HCC. Aggregation-induced emission (AIE) is a phenomenon where the luminescence of certain molecules, typically non-luminescent or weakly luminescent in solution, is significantly enhanced upon aggregation. AIE has been extensively applied in bioimaging, biosensors, and therapy. Fluorophore materials based on AIE (AIEgens) have a wide range of application scenarios and potential for clinical translation. This review focuses on recent advances in AIE-based strategies for diagnosing and treating HCC. First, the specific functional mechanism of AIE is described. Next, we summarize recent progress in the application of AIE for multimodal imaging, biosensor detection, and phototherapy. Finally, prospects and challenges for the AIE-based application in the diagnosis and therapy of HCC are discussed.
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页数：19
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