Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives

被引：0
作者：
Mohammadi, Rezvan [1 ]
Ghani, Sepideh [1 ,2 ,4 ]
Arezumand, Roghaye [3 ]
Farhadi, Shohreh [1 ]
Khazaee-poul, Yalda [1 ]
Kazemi, Bahram [1 ,4 ]
Yarian, Fatemeh [5 ]
Noruzi, Somaye [6 ]
Alibakhshi, Abbas [7 ]
Jalili, Mahsa [8 ]
Aghamiri, Shahin [1 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Student Res Comm, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran
[3] North Khorasan Univ Med Sci, Sch Med, Dept Adv Technol, North Khorasan, Iran
[4] Shahid Beheshti Univ Med Sci, Cellular & Mol Biol Res Ctr, Tehran, Iran
[5] Fasa Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Fasa, Iran
[6] Mashhad Univ Med Sci, Fac Med, Dept Med Biotechnol & Nanotechnol, Mashhad, Iran
[7] Hamadan Univ Med Sci, Mol Med Res Ctr, Hamadan, Iran
[8] Univ Copenhagen, Dept Nutr Exercise & Sports, Prevent & Clin Nutr Grp, Copenhagen, Denmark
来源：
CURRENT MOLECULAR MEDICINE | 2024年 / 24卷 / 10期
关键词：
Antibody; derivatives of antibody; endogenous stimuli; exogenous stimuli; stimulus-responsive systems; targeted delivery of antibody; INTENSITY FOCUSED ULTRASOUND; TEMPERATURE-SENSITIVE LIPOSOMES; DRUG-DELIVERY; BREAST-CANCER; MONOCLONAL-ANTIBODY; IMMUNO-ENZYMOSOMES; TUMOR MICROENVIRONMENT; ENHANCED DELIVERY; ANTICANCER DRUG; MEDIATED GENE;
D O I：
10.2174/1566524023666230818093016
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The application of monoclonal antibodies and antibody fragments with the advent of recombinant antibody technology has made notable progress in clinical trials to provide a regulated drug release and extra targeting to the special conditions in the function site. Modification of antibodies has facilitated using mAbs and antibody fragments in numerous models of therapeutic and detection utilizations, such as stimuli-responsive systems. Antibodies and antibody derivatives conjugated with diverse stimuli-responsive materials have been constructed for drug delivery in response to a wide range of endogenous (electric, magnetic, light, radiation, ultrasound) and exogenous (temperature, pH, redox potential, enzymes) stimuli. In this report, we highlighted the recent progress on antibody-conjugated stimuli-responsive and dual/multi-responsive systems that affect modern medicine by improving a multitude of diagnostic and treatment strategies.
引用
收藏
页码：1250 / 1268
页数：19
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