The Stem Cell Niche in Short Bowel Syndrome

被引：0
作者：
Rubin, Deborah C. [1 ]
机构：
[1] Washington Univ, Sch Med, Div Gastroenterol, 660 South Euclid Ave,Box 8124, St Louis, MO 63110 USA
来源：
GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2024年 / 53卷 / 03期
关键词：
Short bowel syndrome; Intestinal adaptation; Stem cells; Stem cell niche; INTESTINAL ADAPTATION; ILEOCECAL RESECTION;
D O I：
10.1016/j.gtc.2024.04.002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Animal models of short bowel syndrome have shown robust intestinal adaptive morphometric responses that include expansion of the Lgr5+ + stem cell and transit amplifying crypt proliferative cell populations. Several of studies in human short bowel syndrome report similar findings, with an expansion of small bowel stem cells and crypt proliferative cells that may be sustained for prolonged intervals post resection. Studies of the stem cell niche in SBS are ongoing; ISEMFs appear to be activated by resection and contribute to the SBS stem cell niche to expand the stem cell population. The contribution of additional stromal cell types to the niche in SBS is still being elucidated, and is an area of active research.
引用
收藏
页码：473 / 480
页数：8
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共 25 条
  • [1] Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell Niche
    Aoki, Reina
    Shoshkes-Carmel, Michal
    Gao, Nan
    Shin, Soona
    May, Catherine L.
    Goson, Maria L.
    Zahm, Adam M.
    Ray, Michael
    Wiser, Caroline L.
    Wright, Christopher V. E.
    Kaestner, Klaus H.
    [J]. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2016, 2 (02): : 175 - 188
  • [2] Identification of stem cells in small intestine and colon by marker gene Lgr5
    Barker, Nick
    van Es, Johan H.
    Kuipers, Jeroen
    Kujala, Pekka
    van den Born, Maaike
    Cozijnsen, Miranda
    Haegebarth, Andrea
    Korving, Jeroen
    Begthel, Harry
    Peters, Peter J.
    Clevers, Hans
    [J]. NATURE, 2007, 449 (7165) : 1003 - U1
  • [3] Short-bowel syndrome
    Buchman, AL
    [J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2005, 3 (11) : 1066 - 1070
  • [4] GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells
    Degirmenci, Bahar
    Valenta, Tomas
    Dimitrieva, Slavica
    Hausmann, George
    Basler, Konrad
    [J]. NATURE, 2018, 558 (7710) : 449 - +
  • [5] Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice
    Dekaney, Christopher M.
    Fong, Jerry J.
    Rigby, Rachael J.
    Lund, P. Kay
    Henning, Susan J.
    Helmrath, Michael A.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2007, 293 (05): : G1013 - G1022
  • [6] Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion
    Garrison, Aaron P.
    Dekaney, Christopher M.
    von Allmen, Douglas C.
    Lund, P. Kay
    Henning, Susan J.
    Helmrath, Michael A.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2009, 296 (03): : G643 - G650
  • [7] Stem cell and niche regulation in human short bowel syndrome
    Gazit, Vered A.
    Swietlicki, Elzbieta A.
    Liang, Miranda U.
    Surti, Adam
    McDaniel, Raechel
    Geisman, Mackenzie
    Alvarado, David M.
    Ciorba, Matthew A.
    Bochicchio, Grant
    Ilahi, Obeid
    Kirby, John
    Symons, William J.
    Davidson, Nicholas O.
    Levin, Marc S.
    Rubin, Deborah C.
    [J]. JCI INSIGHT, 2020, 5 (23)
  • [8] PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo
    Greicius, Gediminas
    Kabiri, Zahra
    Sigmundsson, Kristmundur
    Liang, Chao
    Bunte, Ralph
    Singh, Manvendra K.
    Virshup, David M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (14) : E3173 - E3181
  • [9] Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome
    Jeppesen, P. B.
    Gilroy, R.
    Pertkiewicz, M.
    Allard, J. P.
    Messing, B.
    O'Keefe, S. J.
    [J]. GUT, 2011, 60 (07) : 902 - 914
  • [10] Teduglutide, a novel glucagon-like peptide 2 analog, in the treatment of patients with short bowel syndrome
    Jeppesen, Palle Bekker
    [J]. THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, 2012, 5 (03) : 159 - 171
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