Efficacy of sulodexide in treating idiopathic membranous nephropathy among Chinese patients: a meta-analysis

被引：0
作者：
Wang, Tao [1 ]
Xu, Jiwen [2 ]
Sun, Yiming [3 ]
Liu, Li [4 ]
Li, Yue [3 ]
Cai, Xiaojun [1 ]
Chen, Ming [5 ]
Fang, Yingying [6 ]
机构：
[1] Heilongjiang Acad Tradit Chinese Med, Dept Endocrinol, Harbin, Heilongjiang, Peoples R China
[2] Heilongjiang Univ Chinese Med, Sch Basic Med Sci, Harbin, Heilongjiang, Peoples R China
[3] Heilongjiang Acad Tradit Chinese Med, Dept Androl, Harbin, Heilongjiang, Peoples R China
[4] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Gynecol, Harbin, Heilongjiang, Peoples R China
[5] Heilongjiang Acad Tradit Chinese Med, Dept Nephropathy, 78 Xiangan St, Harbin 150036, Heilongjiang, Peoples R China
[6] Heilongjiang Acad Tradit Chinese Med, Dept Hepatobil Spleen & Stomach Dis, 78 Xiangan St, Harbin 150036, Heilongjiang, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2024年 / 16卷 / 07期
关键词：
Sulodexide; idiopathic membranous nephropathy; systematic review; meta-analysis; NEPHROTIC SYNDROME;
D O I：
10.62347/RNLQ2888
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: To evaluate the efficacy of Sulodexide in treating idiopathic membranous nephropathy (IMN) in the Chinese population. Methods: We systematically reviewed all eligible randomized clinical trials (RCTs) conducted in China that investigated the effects of Sulodexide on IMN. Three RCTs published between 2013 and 2022 were included, encompassing a total of 146 patients. The primary outcomes evaluated were changes in urine total protein (UTP), serum albumin (ALB), cholesterol (CHOL), and fibrinogen (FIB) levels. Results: Statistically significant differences were observed in the Sulodexide treatment group compared to the control group for the following parameters: reduction in UTP and CHOL, increase in ALB, and reduction in FIB levels. Conclusion: Sulodexide, when combined with conventional therapy, effectively reduces UTP and CHOL levels, decreases FIB levels, and increases ALB in Chinese patients with IMN.
引用
收藏
页码：2756 / 2764
页数：9
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