Role of Antibodies and Their Specificities in Atherosclerotic Cardiovascular Disease

被引：0

作者：

Deroissart, Justine ^{[1
]}

Binder, Christoph J. ^{[1
]}

Porsch, Florentina ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Lab Med, Waehringer Guertel 18-20, A-1090 Vienna, Austria

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2024年 / 44卷 / 10期

基金：

奥地利科学基金会;

关键词：

adaptive immunity; antibodies; antigens; atherosclerosis; lipids; LOW-DENSITY-LIPOPROTEIN; OXIDATION-SPECIFIC EPITOPES; TREATMENT REDUCES ATHEROSCLEROSIS; MODIFIED APOLIPOPROTEIN B100; HEAT-SHOCK PROTEINS; OXIDIZED LDL; IMMUNE-COMPLEXES; APOPTOTIC CELLS; MYOCARDIAL-INFARCTION; B-CELLS;

D O I：

10.1161/ATVBAHA.124.319843

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is a lipid-driven chronic inflammatory disease that is modulated by innate and adaptive immunity including humoral immunity. Importantly, antibody alterations achieved by genetic means or active and passive immunization strategies in preclinical studies can improve or aggravate atherosclerosis. Additionally, a wide range of epidemiological data demonstrate not only an association between the total levels of different antibody isotypes but also levels of antibodies targeting specific antigens with atherosclerotic cardiovascular disease. Here, we discuss the potential role of atherogenic dyslipidemia on the antibody repertoire and review potential antibody-mediated effector mechanisms involved in atherosclerosis development highlighting the major atherosclerosis-associated antigens that trigger antibody responses.

引用

页码：2154 / 2168

页数：15

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