Torque Teno Virus: A Promising Biomarker in Kidney Transplant Recipients

被引：3

作者：

Dal Lago, Sara ^{[1
]}

Brani, Paola ^{[2
]}

Ietto, Giuseppe ^{[2
]}

Dalla Gasperina, Daniela ^{[2
]}

Gianfagna, Francesco ^{[3
,4
]}

Giaroni, Cristina ^{[2
]}

Bosi, Annalisa ^{[3
]}

Ferrante, Francesca Drago ^{[5
]}

Genoni, Angelo ^{[2
]}

Manzoor, Hafza Zahira ^{[2
]}

Ambrosini, Andrea ^{[1
]}

De Cicco, Marco ^{[1
]}

Quartarone, Corradina Dina ^{[1
]}

Khemara, Sara ^{[1
]}

Carcano, Giulio ^{[2
]}

Maggi, Fabrizio ^{[6
]}

Baj, Andreina ^{[2
]}

机构：

[1] Univ Insubria, Nephrol Dept, ASST Sette Laghi, I-21100 Varese, Italy

[2] Univ Insubria, Dept Med & Technol Innovat, I-21100 Varese, Italy

[3] Univ Insubria, Dept Med & Surg, I-21100 Varese, Italy

[4] Mediterranea Cardioctr, I-80122 Naples, Italy

[5] ASST Sette Laghi, Lab Microbiol, I-21100 Varese, Italy

[6] IRCCS, Lab Virol, Natl Inst Infect Dis L Spallanzani, I-00149 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 14期

关键词：

Torque Teno Virus; anellovirus; immunosuppression; kidney transplantation; immunosuppressive therapy; infection; CYTOMEGALOVIRUS-INFECTION; HUMAN VIROME; TTV; IMMUNOSUPPRESSION; LOAD; TORQUETENOVIRUS; TACROLIMUS; MANAGEMENT; KINETICS; DIALYSIS;

D O I：

10.3390/ijms25147744

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Torque Teno Virus (TTV) is a ubiquitous component of the human virome, not associated with any disease. As its load increases when the immune system is compromised, such as in kidney transplant (KT) recipients, TTV load monitoring has been proposed as a method to assess immunosuppression. In this prospective study, TTV load was measured in plasma and urine samples from 42 KT recipients, immediately before KT and in the first 150 days after it. Data obtained suggest that TTV could be a relevant marker for evaluating immune status and could be used as a guide to predict the onset of infectious complications in the follow-up of KT recipients. Since we observed no differences considering distance from transplantation, while we found a changing trend in days before viral infections, we suggest to consider changes over time in the same subjects, irrespective of time distance from transplantation.

引用

页数：15

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