Edaravone: A Possible Treatment for Acute Lung Injury

被引：2
作者：
Huang, Ma [1 ]
Mo, Yalan [2 ]
Lei, Haiyun [1 ]
Chen, Miao [1 ]
机构：
[1] Zunyi Med Univ, Dept Crit Care Med, Affiliated Hosp, Zunyi, Guizhou, Peoples R China
[2] Hunan Med Coll, Gen Hosp, Ctr Infect Dis, Huaihua, Hunan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF GENERAL MEDICINE | 2024年 / 17卷
基金：
中国国家自然科学基金;
关键词：
acute lung injury; edaravone; oxidative stress; inflammation; apoptosis; fibrosis; FREE-RADICAL SCAVENGER; RESPIRATORY-DISTRESS-SYNDROME; ISCHEMIA-REPERFUSION INJURY; SMOKE-INHALATION INJURY; ACUTE-PANCREATITIS; OXIDATIVE STRESS; PROTECTS; INFLAMMATION; STROKE; DAMAGE;
D O I：
10.2147/IJGM.S467891
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Despite technological advances in science and medicine, acute lung injury (ALI) is still associated with high mortality rates in the ICU. Therefore, finding novel drugs and treatment approaches is crucial to preventing ALI. Drug repurposing is a common practice in clinical research, primarily for drugs that have previously received approval for use in patients, to investigate novel uses of drugs and therapies. One such medication is edaravone, which is a highly effective free-radical scavenger that also has antiinflammatory, anti-apoptotic, antioxidant, and anti-fibrotic effects. Both basic and clinical studies have shown that edaravone can treat different types of lung injury through its distinct properties. Edaravone exhibits significant protective benefits and holds promising clinical treatment potential for ALI caused by diverse factors, thereby offering a novel approach to treating ALI. This study aims to provide new insights and treatment options for ALI by reviewing both basic and clinical research on the use of edaravone. The focus is on evaluating the effectiveness of edaravone in treating ALI caused by various factors.
引用
收藏
页码：3975 / 3986
页数：12
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