Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept

被引：0

作者：

Boffini, Massimo ^{[1
]}

Costamagna, Andrea ^{[2
]}

Marro, Matteo ^{[1
]}

Simonato, Erika ^{[1
]}

Cassoni, Paola ^{[3
]}

Bertero, Luca ^{[3
]}

Fanelli, Vito ^{[2
]}

Barbero, Cristina ^{[1
]}

Brazzi, Luca ^{[2
]}

Rinaldi, Mauro ^{[1
]}

机构：

[1] Univ Torino, Surg Sci Dept, Cardiac Surg Div, Citta Salute & Sci, Turin, Italy

[2] Univ Torino, Citta Salute & Sci, Surg Sci Dept, Anesthesiol & Intens Care Div, Turin, Italy

[3] Univ Torino, Citta Salute & Sci, Pathol Unit, Med Sci Dept, Turin, Italy

来源：

TRANSPLANT INTERNATIONAL | 2024年 / 37卷

关键词：

lung transplant; animal model; EVLP; organ preservation; perfusion; TRANSPLANTATION; INFECTION; POSITION; IMPACT;

D O I：

10.3389/ti.2024.13178

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The key goal in lung donation remains the improvement of graft preservation with the ultimate objective of increasing the number and quality of lung transplants (LTx). Therefore, in recent years the field of graft preservation focused on improving outcomes related to solid organ regeneration and restoration. In this contest Ex-Vivo Lung Perfusion (EVLP) plays a crucial role with the purpose to increase the donor pool availability transforming marginal and/or declined donor lungs suitable for transplantation. Aim of this proof of concept is to test the safety, suitability and feasibility of a new tilting dome for EVLP designed considering the dorsal lung areas as the "Achilles' heel" of the EVLP due to a more fluid accumulation than in the supine standard position.

引用

页数：7

共 23 条

[1] Ex vivo lung perfusion in clinical lung transplantation-State of the art [J].

Andreasson, Anders S. I. ;

Dark, John H. ;

Fisher, Andrew J. .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2014, 46 (05) :779-788

[2] Ex Vivo Lung Perfusion Increases the Pool of Lung Grafts: Analysis of Its Potential and Real Impact on a Lung Transplant Program [J].

Boffini, M. ;

Ricci, D. ;

Barbero, C. ;

Bonato, R. ;

Ribezzo, M. ;

Mancuso, E. ;

Attisani, M. ;

Simonato, E. ;

Magistroni, P. ;

Mansouri, M. ;

Solidoro, P. ;

Baldi, S. ;

Pasero, D. ;

Amoroso, A. ;

Rinaldi, M. .

TRANSPLANTATION PROCEEDINGS, 2013, 45 (07) :2624-2626

[3] Cytokines Removal During Ex-Vivo Lung Perfusion: Initial Clinical Experience [J].

Boffini, Massimo ;

Marro, Matteo ;

Simonato, Erika ;

Scalini, Fabrizio ;

Costamagna, Andrea ;

Fanelli, Vito ;

Barbero, Cristina ;

Solidoro, Paolo ;

Brazzi, Luca ;

Rinaldi, Mauro .

TRANSPLANT INTERNATIONAL, 2023, 36

[4] Is there life on the airway tree? A pilot study of bronchial cell vitality and tissue morphology in the ex vivo lung perfusion (EVLP) era of lung transplantation [J].

Boffini, Massimo ;

Cassoni, Paola ;

Gambella, Alessandro ;

Simonato, Erika ;

Delsedime, Luisa ;

Marro, Matteo ;

Fanelli, Vito ;

Costamagna, Andrea ;

Lausi, Paolo Olivo ;

Solidoro, Paolo ;

Scalini, Fabrizio ;

Barbero, Cristina ;

Brazzi, Luca ;

Rinaldi, Mauro ;

Bertero, Luca .

ARTIFICIAL ORGANS, 2022, 46 (11) :2234-2243

[5] Incidence and severity of primary graft dysfunction after lung transplantation using rejected grafts reconditioned with ex vivo lung perfusion [J].

Boffini, Massimo ;

Ricci, Davide ;

Bonato, Riccardo ;

Fanelli, Vito ;

Attisani, Matteo ;

Ribezzo, Marco ;

Solidoro, Paolo ;

Del Sorbo, Lorenzo ;

Ranieri, Vito Marco ;

Rinaldi, Mauro .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2014, 46 (05) :789-793

[6] The potential role of ex vivo lung perfusion for the diagnosis of infection before lung transplantation [J].

Boffini, Massimo ;

Bonato, Riccardo ;

Rinaldi, Mauro .

TRANSPLANT INTERNATIONAL, 2014, 27 (02) :E5-E7

[7] Lung transplantation: is it still an experimental procedure? [J].

Boffini, Massimo ;

Ranieri, Vito M. ;

Rinaldi, Mauro .

CURRENT OPINION IN CRITICAL CARE, 2010, 16 (01) :53-61

[8] Clinical performance of lung ultrasound in predicting graft outcome during ex-vivo lung perfusion [J].

Costamagna, Andrea ;

Steinberg, Irene ;

Simonato, Erika ;

Massaro, Cristiano ;

Filippini, Claudia ;

Rinaldi, Mauro ;

Brazzi, Luca ;

Boffini, Massimo ;

Fanelli, Vito .

MINERVA ANESTESIOLOGICA, 2021, 87 (07) :837-839

[9] Ex vivo perfusion techniques: state of the art and potential applications [J].

Cypel, Marcelo ;

Neyrinck, Arne ;

Machuca, Tiago N. .

INTENSIVE CARE MEDICINE, 2019, 45 (03) :354-356

[10] Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation [J].

Cypel, Marcelo ;

Yeung, Jonathan C. ;

Liu, Mingyao ;

Anraku, Masaki ;

Chen, Fengshi ;

Karolak, Wojtek ;

Sato, Masaaki ;

Laratta, Jane ;

Azad, Sassan ;

Madonik, Mindy ;

Chow, Chung-Wai ;

Chaparro, Cecilia ;

Hutcheon, Michael ;

Singer, Lianne G. ;

Slutsky, Arthur S. ;

Yasufuku, Kazuhiro ;

de Perrot, Marc ;

Pierre, Andrew F. ;

Waddell, Thomas K. ;

Keshavjee, Shaf .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (15) :1431-1440

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