The role of CD8 PET imaging in guiding cancer immunotherapy

被引：1
作者：
Zhang, Jiani [1 ]
Du, Bulin [1 ]
Wang, Yuxiang [1 ]
Cui, Yan [1 ]
Wang, Shu [1 ]
Zhao, Yuxuan [1 ]
Li, Yaming [1 ]
Li, Xuena [1 ]
机构：
[1] China Med Univ, Hosp 1, Dept Nucl Med, Shenyang, Liaoning, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
immunotherapy; CD8+T cells; PET; clinical application; cancer; TUMOR-INFILTRATING LYMPHOCYTES; T-CELL-ACTIVATION; GRANZYME-B; IMMUNO-PET; CHECKPOINT INHIBITOR; RESPONSES; BLOCKADE; PERFORIN; THERAPY; INNATE;
D O I：
10.3389/fimmu.2024.1428541
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Currently, immunotherapy is being widely used for treating cancers. However, the significant heterogeneity in patient responses is a major challenge for its successful application. CD8-positive T cells (CD8+ T cells) play a critical role in immunotherapy. Both their infiltration and functional status in tumors contribute to treatment outcomes. Therefore, accurate monitoring of CD8+ T cells, a potential biomarker, may improve therapeutic strategy. Positron emission tomography (PET) is an optimal option which can provide molecular imaging with enhanced specificity. This review summarizes the mechanism of action of CD8+ T cells in immunotherapy, and highlights the recent advancements in PET-based tracers that can visualize CD8+ T cells and discusses their clinical applications to elucidate their potential role in cancer immunotherapy.
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页数：14
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