Therapeutic Effects of Wharton's Jelly Mesenchymal Stem Cells: from Laboratory to Clinical Application

被引：1
作者：
Azarbarz, Nastaran [1 ]
Rezaei-Tazangi, Fatemeh [2 ]
Seifabadi, Zeinab Shafiei [3 ]
Nejad, Darioush Bijan [3 ,4 ]
机构：
[1] Arak Univ Med Sci, Sch Med, Dept Anat, Arak, Iran
[2] Fasa Univ Med Sci, Sch Med, Dept Anat, Fasa, Iran
[3] Behbahan Fac Med Sci, Behbahan, Iran
[4] Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Cellular & Mol Res Ctr, Ahvaz, Iran
来源：
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY | 2024年 / 67卷
关键词：
Wharton's jelly; mesenchymal stem cells; umbilical cord; Cancer; wound; UMBILICAL-CORD; CONDITIONED MEDIUM; STROMAL CELLS; TRANSPLANTATION; DIFFERENTIATION; PROLIFERATION; BLOOD; TUMORIGENESIS; MECHANISMS; EXPRESSION;
D O I：
10.1590/1678-4324-2024220300
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Stem cells are a promising solution for repaired damage tissue. Isolation of this cell from tissue, proliferation in vitro, and implanting them in damaged tissue microenvironment are the basic strategy of Regenerative medicine. Mesenchymal stem cells (MSCs) have unique therapeutics function such as homing to target tissue and stimulating host cell regeneration, repairing damaged cells, autocrine/paracrine effects, immune modulation and several lineages differentiation. For this reason, MSCs are appropriate choice for tissue engineering and cell based therapy. Umbilical cord as a commonly discarded tissue, which are obtained non- invasively. Umbilical cord contains Wharton's jelly (WJ), a gelatin substance surrounding umbilical cord vessels. WJ, a rich source of self-renewal MSCs with extended proliferation and multilineage differentiation potential can be a best option for Regenerative medicine based on cell- therapy. In this chapter, we will discuss an outline of the recent findings related to Wharton's jelly Mesenchymal stem cells (WJMSCs) and its therapeutic effects and possible advantage they possess.
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页数：11
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