Protein tyrosine phosphatase 1B in metabolic and cardiovascular diseases: from mechanisms to therapeutics

被引:1
|
作者
Sun, Yan [1 ]
Dinenno, Frank A. [1 ]
Tang, Peiyang [1 ]
Kontaridis, Maria I. [1 ,2 ,3 ]
机构
[1] Masonic Med Res Inst, Dept Biomed Res & Translat Med, Utica, NY 13501 USA
[2] Beth Israel Deaconess Med Ctr, Dept Med, Div Cardiol, Boston, MA 02215 USA
[3] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
来源
基金
美国国家卫生研究院;
关键词
protein tyrosine phosphatase 1B (PTP1B); cardiovascular disease; insulin resistance; diabetes; obesity; therapeutics; MUSCLE-CELL MOTILITY; GROWTH-FACTOR; INSULIN-RECEPTOR; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; ENDOPLASMIC-RETICULUM; GLUCOSE-HOMEOSTASIS; PTP1B INHIBITORS; BLOOD-PRESSURE; OBESITY;
D O I
10.3389/fcvm.2024.1445739
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Protein Tyrosine Phosphatase 1B (PTP1B) has emerged as a significant regulator of metabolic and cardiovascular disease. It is a non-transmembrane protein tyrosine phosphatase that negatively regulates multiple signaling pathways integral to the regulation of growth, survival, and differentiation of cells, including leptin and insulin signaling, which are critical for development of obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. Given PTP1B's central role in glucose homeostasis, energy balance, and vascular function, targeted inhibition of PTP1B represents a promising strategy for treating these diseases. However, challenges, such as off-target effects, necessitate a focus on tissue-specific approaches, to maximize therapeutic benefits while minimizing adverse outcomes. In this review, we discuss molecular mechanisms by which PTP1B influences metabolic and cardiovascular functions, summarize the latest research on tissue-specific roles of PTP1B, and discuss the potential for PTP1B inhibitors as future therapeutic agents.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] Role of protein tyrosine phosphatase 1B in cardiovascular diseases
    Thiebaut, Pierre-Alain
    Besnier, Marie
    Gomez, Elodie
    Richard, Vincent
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2016, 101 : 50 - 57
  • [2] Protein tyrosine phosphatase 1B in metabolic diseases and drug development
    Delibegovic, Mirela
    Dall'Angelo, Sergio
    Dekeryte, Ruta
    NATURE REVIEWS ENDOCRINOLOGY, 2024, 20 (06) : 366 - 378
  • [3] Protein tyrosine phosphatase 1B in metabolic diseases and drug development
    Mirela Delibegović
    Sergio Dall’Angelo
    Ruta Dekeryte
    Nature Reviews Endocrinology, 2024, 20 : 366 - 378
  • [4] Mechanisms for allosteric inhibition of protein tyrosine phosphatase 1B
    Hendrickson, Heidi
    Lipchock, James
    Douglas, Bonnie
    Rivalta, Ivan
    Ten, Nicholas
    Batista, Victor
    Loria, J. Patrick
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
  • [5] Protein-tyrosine phosphatase 1B substrates and metabolic regulation
    Bakke, Jesse
    Haj, Fawaz G.
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2015, 37 : 58 - 65
  • [6] Protein tyrosine phosphatase 1B in hematopoiesis
    Heinonen, Krista M.
    Tremblay, Michel L.
    CELL CYCLE, 2006, 5 (10) : 1053 - 1056
  • [7] Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
    Feng, Xiaojun
    Sureda, Antoni
    Jafari, Samineh
    Memariani, Zahra
    Tewari, Devesh
    Annunziata, Giuseppe
    Barrea, Luigi
    Hassan, Sherif T. S.
    Smejkal, Karel
    Malanik, Milan
    Sychrova, Alice
    Barreca, Davide
    Ziberna, Lovro
    Mahomoodally, Mohamad Fawzi
    Zengin, Gokhan
    Xu, Suowen
    Nabavi, Seyed Mohammad
    Shen, Ai-Zong
    THERANOSTICS, 2019, 9 (07): : 1923 - 1951
  • [8] Protein tyrosine phosphatase 1B inhibitors from natural sources
    Bing Tian Zhao
    Duc Hung Nguyen
    Duc Dat Le
    Jae Sue Choi
    Byung Sun Min
    Mi Hee Woo
    Archives of Pharmacal Research, 2018, 41 : 130 - 161
  • [9] Protein tyrosine phosphatase 1B inhibitors from natural sources
    Zhao, Bing Tian
    Duc Hung Nguyen
    Le, Duc Dat
    Choi, Jae Sue
    Min, Byung Sun
    Woo, Mi Hee
    ARCHIVES OF PHARMACAL RESEARCH, 2018, 41 (02) : 130 - 161
  • [10] Protein Tyrosine Phosphatase 1B Inhibitors from Plantago asiatica
    LEE Hyun-sun
    AHN Jong-seog
    Chinese Herbal Medicines, 2011, 3 (02) : 136 - 139