Tumor-infiltrating B cells: Their dual mechanistic roles in the tumor microenvironment

被引：8
作者：
Xue, Demin [1 ]
Hu, Shaozhen [2 ]
Zheng, Runchen [1 ]
Luo, Huidan [3 ]
Ren, Xi [4 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Sch Chinese Class, Chengdu 611137, Peoples R China
[2] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou 510006, Peoples R China
[3] Hechi Hosp Tradit Chinese Med, Dept Pulmonol, Hechi 547000, Guangxi, Peoples R China
[4] Southern Med Univ, Southern Med Univ Hosp Integrated Tradit Chinese &, Dept Oncol 2, Guangzhou 510515, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 179卷
关键词：
Tumor-infiltrating B cells; Tumor microenvironment; Immune microenvironment; Immunotherapy; T-CELL; PLASMA-CELLS; ANTITUMOR IMMUNITY; BREAST-CANCER; LYMPHOCYTES; IMMUNOTHERAPY; ANTIGEN; RESPONSES; INFLAMMATION; CHEMOTHERAPY;
D O I：
10.1016/j.biopha.2024.117436
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The occurrence and development of tumors are closely associated with abnormalities in the immune system's structure and function, with tumor immunotherapy being intricately linked to the tumor microenvironment (TME). Early studies on lymphocytes within the TME primarily concentrated on T cells. However, as research has advanced, the multifaceted roles of tumor-infiltrating B cells (TIL-Bs) in tumor immunity, encompassing both anti-tumor and pro-tumor effects, have garnered increasing attention. This paper explored the composition of the TME and the biological characteristics of TIL-Bs, investigating the dual roles within the TME to offer new insights and strategies for tumor immunotherapy.
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页数：10
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