Impact of molecular testing on the surgical management of advanced epithelial ovarian cancer

被引：2
作者：
Colombo, Pierre-Emmanuel [1 ]
Taoum, Christophe [1 ]
Fabbro, Michel [2 ]
Quesada, Stanislas [2 ]
Rouanet, Philippe [1 ]
Ray-Coquard, Isabelle [3 ]
机构：
[1] Montpellier Canc Inst ICM, Dept Surg Oncol, 208 Rue Apothicaires,Parc Euromed, F-34298 Montpellier 5, France
[2] Montpellier Canc Inst ICM, Dept Med Oncol, Montpellier, France
[3] Leon Berard Ctr, Dept Med Oncol, Lyon, France
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2024年 / 202卷
关键词：
Ovarian cancer; Surgery; BRCA mutation; Homologous Recombination Deficiency (HRD); Lymphadenectomy; Residual disease; First-line treatement; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; MUTATION-POSITIVE WOMEN; GRADE SEROUS CARCINOMA; BRCA2; MUTATIONS; NEOADJUVANT CHEMOTHERAPY; MAINTENANCE THERAPY; GERMLINE MUTATION; INVASION PATTERNS; SURVIVAL; CYTOREDUCTION;
D O I：
10.1016/j.critrevonc.2024.104469
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian carcinoma remains the most lethal gynaecologic malignancy. Half of all high-grade serous ovarian cancers (HGSOCs) have a homologous recombination deficiency (HRD) with regard to the repair of double-strand DNA breaks and are candidate to receive maintenance treatment with PARP inhibitors. While a wealth of literature exists regarding the therapeutic guidance of patients from a medical standpoint, the influence of the HRD status on the surgical outlook has been comparatively limited. In this review, the clinical and biological features of advanced ovarian cancers with BRCA1/2 mutation and/or HRD status are considered with particular reference to their impact on the surgical management and on the medico-surgical sequence. The modification of the surgical indications according to the results of molecular testing in first-line and recurrent settings are discussed.
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页数：11
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共 67 条
  • [1] BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation-Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group
    Alsop, Kathryn
    Fereday, Sian
    Meldrum, Cliff
    deFazio, Anna
    Emmanuel, Catherine
    George, Joshy
    Dobrovic, Alexander
    Birrer, Michael J.
    Webb, Penelope M.
    Stewart, Colin
    Friedlander, Michael
    Fox, Stephen
    Bowtell, David
    Mitchell, Gillian
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (21) : 2654 - 2663
  • [2] Characteristics and outcome of BRCA mutated epithelial ovarian cancer patients in Italy: A retrospective multicenter study (MITO 21)
    Artioli, Grazia
    Giannone, Gaia
    Valabrega, Giorgio
    Maggiorotto, Furio
    Genta, Sofia
    Pignata, Sandro
    Lorusso, Domenica
    Cormio, Gennaro
    Scalone, Simona
    Nicoletto, Maria Ornella
    Greco, Filippo
    Rossi, Emanuela
    Spagnoletti, Ilaria
    De Giorgi, Ugo
    Orditura, Michele
    Mosconi, Anna Maria
    Kardhashi, Anila
    Bogliolo, Stefano
    Borgato, Lucia
    [J]. GYNECOLOGIC ONCOLOGY, 2021, 161 (03) : 755 - 761
  • [3] Maintenance olaparib for patients with newly diagnosed advanced ovarian cancer and a BRCA mutation (SOLO1/GOG 3004): 5-year follow-up of a randomised, double-blind, placebo-controlled, phase 3 trial
    Banerjee, Susana
    Moore, Kathleen N.
    Colombo, Nicoletta
    Scambia, Giovanni
    Kim, Byoung-Gie
    Oaknin, Ana
    Friedlander, Michael
    Lisyanskaya, Alla
    Floquet, Anne
    Leary, Alexandra
    Sonke, Gabe S.
    Gourley, Charlie
    Oza, Amit
    Gonzalez-Martin, Antonio
    Aghajanian, Carol
    Bradley, William H.
    Holmes, Eileen
    Lowe, Elizabeth S.
    DiSilvestro, Paul
    [J]. LANCET ONCOLOGY, 2021, 22 (12) : 1721 - 1731
  • [4] Integrated genomic analyses of ovarian carcinoma
    Bell, D.
    Berchuck, A.
    Birrer, M.
    Chien, J.
    Cramer, D. W.
    Dao, F.
    Dhir, R.
    DiSaia, P.
    Gabra, H.
    Glenn, P.
    Godwin, A. K.
    Gross, J.
    Hartmann, L.
    Huang, M.
    Huntsman, D. G.
    Iacocca, M.
    Imielinski, M.
    Kalloger, S.
    Karlan, B. Y.
    Levine, D. A.
    Mills, G. B.
    Morrison, C.
    Mutch, D.
    Olvera, N.
    Orsulic, S.
    Park, K.
    Petrelli, N.
    Rabeno, B.
    Rader, J. S.
    Sikic, B. I.
    Smith-McCune, K.
    Sood, A. K.
    Bowtell, D.
    Penny, R.
    Testa, J. R.
    Chang, K.
    Dinh, H. H.
    Drummond, J. A.
    Fowler, G.
    Gunaratne, P.
    Hawes, A. C.
    Kovar, C. L.
    Lewis, L. R.
    Morgan, M. B.
    Newsham, I. F.
    Santibanez, J.
    Reid, J. G.
    Trevino, L. R.
    Wu, Y. -Q.
    Wang, M.
    [J]. NATURE, 2011, 474 (7353) : 609 - 615
  • [5] Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma
    Boehm, Steffen
    Faruqi, Asma
    Said, Ian
    Lockley, Michelle
    Brockbank, Elly
    Jeyarajah, Arjun
    Fitzpatrick, Amanda
    Ennis, Darren
    Dowe, Thomas
    Santos, Jennifer L.
    Cook, Linda S.
    Tinker, Anna V.
    Le, Nhu D.
    Gilks, C. Blake
    Singh, Naveena
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (22) : 2457 - U73
  • [6] Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer
    Bolton, Kelly L.
    Chenevix-Trench, Georgia
    Goh, Cindy
    Sadetzki, Siegal
    Ramus, Susan J.
    Karlan, Beth Y.
    Lambrechts, Diether
    Despierre, Evelyn
    Barrowdale, Daniel
    McGuffog, Lesley
    Healey, Sue
    Easton, Douglas F.
    Sinilnikova, Olga
    Benitez, Javier
    Garcia, Maria J.
    Neuhausen, Susan
    Gail, Mitchell H.
    Hartge, Patricia
    Peock, Susan
    Frost, Debra
    Evans, Gareth
    Eeles, Rosalind
    Godwin, Andrew K.
    Daly, Mary B.
    Kwong, Ava
    Ma, Edmond S. K.
    Lazaro, Conxi
    Blanco, Ignacio
    Montagna, Marco
    D'Andrea, Emma
    Nicoletto, Maria Ornella
    Johnatty, Sharon E.
    Krueger, Susanne
    Jensen, Allan
    Hogdall, Estrid
    Goode, Ellen L.
    Fridley, Brooke L.
    Loud, Jennifer T.
    Greene, Mark H.
    Mai, Phuong L.
    Chetrit, Angela
    Lubin, Flora
    Hirsh-Yechezkel, Galit
    Glendon, Gord
    Andrulis, Irene L.
    Toland, Amanda E.
    Senter, Leigha
    Gore, Martin E.
    Gourley, Charlie
    Michie, Caroline O.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (04): : 382 - 390
  • [7] Clinicopathologic features of BRCA-linked and sporadic ovarian cancer
    Boyd, J
    Sonoda, Y
    Federici, MG
    Bogomolniy, F
    Rhei, E
    Maresco, DL
    Saigo, PE
    Almadrones, LA
    Barakat, RR
    Brown, CL
    Chi, DS
    Curtin, JP
    Poynor, EA
    Hoskins, WJ
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (17): : 2260 - 2265
  • [8] Germline Mutation in BRCA1 or BRCA2 and Ten-Year Survival for Women Diagnosed with Epithelial Ovarian Cancer
    Candido-dos-Reis, Francisco J.
    Song, Honglin
    Goode, Ellen L.
    Cunningham, Julie M.
    Fridley, Brooke L.
    Larson, Melissa C.
    Alsop, Kathryn
    Dicks, Ed
    Harrington, Patricia
    Ramus, Susan J.
    de Fazio, Anna
    Mitchell, Gillian
    Fereday, Sian
    Bolton, Kelly L.
    Gourley, Charlie
    Michie, Caroline
    Karlan, Beth
    Lester, Jenny
    Walsh, Christine
    Cass, Ilana
    Olsson, Hakan
    Gore, Martin
    Benitez, Javier J.
    Garcia, Maria J.
    Andrulis, Irene
    Mulligan, Anna Marie
    Glendon, Gord
    Blanco, Ignacio
    Lazaro, Conxi
    Whittemore, Alice S.
    McGuire, Valerie
    Sieh, Weiva
    Montagna, Marco
    Alducci, Elisa
    Sadetzki, Siegal
    Chetrit, Angela
    Kwong, Ava
    Kjaer, Susanne K.
    Jensen, Allan
    Hogdall, Estrid
    Neuhausen, Susan
    Nussbaum, Robert
    Daly, Mary
    Greene, Mark H.
    Mai, Phuong L.
    Loud, Jennifer T.
    Moysich, Kirsten
    Toland, Amanda E.
    Lambrechts, Diether
    Ellis, Steve
    [J]. CLINICAL CANCER RESEARCH, 2015, 21 (03) : 652 - 657
  • [9] Cytoreductive surgery followed by chemotherapy and olaparib maintenance in BRCA 1/2 mutated recurrent ovarian cancer: a retrospective MITO group study
    Cecere, Sabrina Chiara
    Musacchio, Lucia
    Bartoletti, Michele
    Salutari, Vanda
    Arenare, Laura
    Lorusso, Domenica
    Ronzino, Graziana
    Lauria, Rossella
    Cormio, Gennaro
    Naglieri, Emanuele
    Scollo, Paolo
    Marchetti, Claudia
    Raspagliesi, Francesco
    Greggi, Stefano
    Cinieri, Saverio
    Bergamini, Alice
    Orditura, Michele
    Valabrega, Giorgio
    Scambia, Giovanni
    Martinelli, Fabio
    De Matteis, Elisabetta
    Cardalesi, Cinzia
    Loizzi, Vera
    Perniola, Giorgia
    Carella, Claudia
    Scandurra, Giuseppa
    Giannone, Gaia
    Pignata, Sandro
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2021, 31 (07) : 1031 - 1036
  • [10] Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer
    Coleman, R. L.
    Fleming, G. F.
    Brady, M. F.
    Swisher, E. M.
    Steffensen, K. D.
    Friedlander, M.
    Okamoto, A.
    Moore, K. N.
    Ben-Baruch, N. Efrat
    Werner, T. L.
    Cloven, N. G.
    Oaknin, A.
    DiSilvestro, P. A.
    Morgan, M. A.
    Nam, J. -H.
    Leath, C. A., III
    Nicum, S.
    Hagemann, A. R.
    Littell, R. D.
    Cella, D.
    Baron-Hay, S.
    Garcia-Donas, J.
    Mizuno, M.
    Bell-McGuinn, K.
    Sullivan, D. M.
    Bach, B. A.
    Bhattacharya, S.
    Ratajczak, C. K.
    Ansell, P. J.
    Dinh, M. H.
    Aghajanian, C.
    Bookman, M. A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (25) : 2403 - 2415
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