The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy

被引：7

作者：

Chen, Fanglu ^{[1
,2
,3
]}

Xue, Yucheng ^{[1
,2
,3
]}

Zhang, Wenkan ^{[1
,2
,3
]}

Zhou, Hao ^{[1
,2
,3
]}

Zhou, Zhiyi ^{[4
]}

Chen, Tao ^{[1
,2
,3
]}

Eloy, Yinwang ^{[1
,2
,3
]}

Li, Hengyuan ^{[1
,2
,3
]}

Ye, Zhaoming ^{[1
,2
,3
]}

Gao, Junjie ^{[5
]}

Wang, Shengdong ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Musculoskeletal Tumor Ctr, Dept Orthoped,Sch Med, Hangzhou 310009, Peoples R China

[2] Zhejiang Univ, Inst Orthoped Res, Hangzhou 310009, Peoples R China

[3] Key Lab Motor Syst Dis Res & Precis Therapy Zhejia, Hangzhou, Zhejiang, Peoples R China

[4] First Peoples Hosp Yuhang Dist, Hangzhou, Zhejiang, Peoples R China

[5] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthopaed, Sch Med, Shanghai 200233, Peoples R China

来源：

CANCER AND METASTASIS REVIEWS | 2024年 / 43卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Tumor metastasis; Metabolism; Mitophagy; Mitochondrial genetics; Mitochondria transfer; Immunotherapy; DNA COPY NUMBER; HEPATOCELLULAR-CARCINOMA METASTASIS; IMMUNOGENIC CELL-DEATH; RANDOMIZED PHASE-II; GLUCOSE-METABOLISM; TUNNELING NANOTUBES; ANTITUMOR-ACTIVITY; PANCREATIC-CANCER; MICROSATELLITE INSTABILITY; MESENCHYMAL TRANSITION;

D O I：

10.1007/s10555-024-10211-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical involvement of specific mitochondrial-associated events, including mitochondrial quality control, intercellular mitochondrial transfer, and mitochondrial genetics, in potentiating the metastatic cascade of neoplastic cells. Furthermore, numerous recent studies have consistently emphasized the highly significant role mitochondria play in coordinating the regulation of tumor-infiltrating immune cells and immunotherapeutic interventions. This review provides a comprehensive and rigorous scholarly investigation of this subject matter, exploring the intricate mechanisms by which mitochondria contribute to tumor metastasis and examining the progress of mitochondria-targeted cancer therapies.

引用

页码：1419 / 1443

页数：25

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