Assessment of current biomarkers and interventions to identify and treat women at risk of preterm birth

被引:1
作者
Gravett, Michael G. [1 ]
Menon, Ramkumar [2 ]
Tribe, Rachel M. [3 ]
Hezelgrave, Natasha L. [4 ]
Kacerovsky, Marian [5 ,6 ]
Soma-Pillay, Priya [7 ]
Jacobsson, Bo [8 ,9 ]
McElrath, Thomas F. [10 ,11 ]
机构
[1] Univ Washington, Dept Obstet & Gynecol & Global Hlth, Seattle, WA 98195 USA
[2] Univ Texas Med Branch Galveston, Dept Obstet & Gynecol, Galveston, TX USA
[3] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Women & Childrens Hlth, St Thomas Hosp Campus, London, England
[4] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Women & Childrens Hlth, London, England
[5] Univ Hosp Hradec Kralove, Biomed Res Ctr, Hradec Kralove, Czech Republic
[6] Charles Univ Prague, Fac Med Hradec Kralove, Dept Obstet & Gynecol, Hradec Kralove, Czech Republic
[7] Univ Pretoria, Dept Obstet & Gynaecol, Sch Med, Pretoria, South Africa
[8] Gothenburg Univ, Sahlgrenska Acad, Dept Obstet & Gynecol, Gothenburg, Sweden
[9] Norwegian Inst Publ Hlth, Dept Genet & Bioinformat, Domain Hlth Data & Digitalizat, Oslo, Norway
[10] Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA USA
[11] Harvard Med Sch, Boston, MA USA
关键词
preterm birth; biomarkers; screening tools; interventions; limitations; QUANTITATIVE FETAL FIBRONECTIN; ACTIM PARTUS TEST; CERVICAL LENGTH; SINGLETON PREGNANCY; GESTATIONAL-AGE; COMMUNICATION; METAANALYSIS; VALIDATION; PREVENTION; PREDICTION;
D O I
10.3389/fmed.2024.1414428
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Preterm birth remains an important global problem, and an important contributor to under-5 mortality. Reducing spontaneous preterm birth rates at the global level will require the early identification of patients at risk of preterm delivery in order to allow the initiation of appropriate prophylactic management strategies. Ideally these strategies target the underlying pathophysiologic causes of preterm labor. Prevention, however, becomes problematic as the causes of preterm birth are multifactorial and vary by gestational age, ethnicity, and social context. Unfortunately, current screening and diagnostic tests are non-specific, with only moderate clinical risk prediction, relying on the detection of downstream markers of the common end-stage pathway rather than identifying upstream pathway-specific pathophysiology that would help the provider initiate targeted interventions. As a result, the available management options (including cervical cerclage and vaginal progesterone) are used empirically with, at best, ambiguous results in clinical trials. Furthermore, the available screening tests have only modest clinical risk prediction, and fail to identify most patients who will have a preterm birth. Clearly defining preterm birth phenotypes and the biologic pathways leading to preterm birth is key to providing targeted, biomolecular pathway-specific interventions, ideally initiated in early pregnancy Pathway specific biomarker discovery, together with management strategies based on early, mid-, and-late trimester specific markers is integral to this process, which must be addressed in a systematic way through rigorously planned biomarker trials.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] The risk of preterm birth among women with a history of leukemia or lymphoma
    Anand, Sonia T.
    Chrischilles, Elizabeth A.
    Baer, Rebecca J.
    Charlton, Mary E.
    Breheny, Patrick J.
    Terry, William W.
    McLemore, Monica R.
    Karasek, Deborah A.
    Jelliffe-Pawlowski, Laura L.
    Ryckman, Kelli K.
    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2022, 35 (25) : 6115 - 6123
  • [22] Early term birth is associated with the risk of preterm and recurrent early term birth in women with 3 consecutive deliveries
    Ashwal, Eran
    Attali, Emmanuel
    Melamed, Nir
    Haratz, Karina Krajden
    Aviram, Amir
    Hadar, Eran
    Yogev, Yariv
    Hiersch, Liran
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2021, 261 : 160 - 165
  • [23] Risk assessment of preterm birth through identification and stratification of pregnancies using a real-time scoring algorithm
    Shields, Lisa B. E.
    Weymouth, Clayton
    Bramer, Kevin L.
    Robinson, Scott
    McGee, Donna
    Richards, Lori
    Ogle, Corey
    Shields, Christopher B.
    SAGE OPEN MEDICINE, 2021, 9
  • [24] Risk factors for recurrent preterm birth in multiparous Utah women: a historical cohort study
    Simonsen, S. E.
    Lyon, J. L.
    Stanford, J. B.
    Porucznik, C. A.
    Esplin, M. S.
    Varner, M. W.
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2013, 120 (07) : 863 - 872
  • [25] How to screen the cervix and reduce the risk of spontaneous preterm birth in asymptomatic women without a prior preterm birth
    Lee, Seon Ui
    Jung, Gyul
    Kim, Han Wool
    Ko, Hyun Sun
    OBSTETRICS & GYNECOLOGY SCIENCE, 2023, 66 (05) : 337 - 346
  • [26] Cervical length, risk factors, and delivery outcomes among women with spontaneous preterm birth
    Boelig, Rupsa C.
    Orzechowski, Kelly M.
    Berghella, Vincenzo
    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2016, 29 (17) : 2840 - 2844
  • [27] Periodontal Pathogens and Preterm Birth: Current Knowledge and Further Interventions
    Terzic, Milan
    Aimagambetova, Gulzhanat
    Terzic, Sanja
    Radunovic, Milena
    Bapayeva, Gauri
    Lagana, Antonio Simone
    PATHOGENS, 2021, 10 (06):
  • [28] Preterm Birth Risk in Women with Uterine Anomalies
    Kausen, Brittany
    Dontsi, Makdine
    Postlethwaite, Debbie A.
    Regenstein, Anne C.
    JOURNAL OF REPRODUCTIVE MEDICINE, 2021, 66 (5-6) : 129 - 135
  • [29] Second trimester cervical length and risk of preterm birth in women with twin gestations treated with 17-α hydroxyprogesterone caproate
    Durnwald, Celeste P.
    Momirova, Valerija
    Rouse, Dwight J.
    Caritis, Steve N.
    Peaceman, Alan M.
    Sciscione, Anthony
    Varner, Michael W.
    Malone, Fergal D.
    Mercer, Brian M.
    Thorp, John M., Jr.
    Sorokin, Yoram
    Carpenter, Marshall W.
    Lo, Julie
    Ramin, Susan M.
    Harper, Margaret
    Spong, Catherine Y.
    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2010, 23 (12) : 1360 - 1364
  • [30] Accuracy of fetal fibronectin for assessing preterm birth risk in asymptomatic pregnant women: a systematic review and meta-analysis
    Dos Santos, Francois
    Daru, Jahnavi
    Rogozinska, Ewelina
    Cooper, Natalie A. M.
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2018, 97 (06) : 657 - 667