Chiral Polymeric Diamine Ligands for Iridium-Catalyzed Asymmetric Transfer Hydrogenation

被引：9

作者：

Lin, Yaodong ^{[1
]}

Xu, Guangqing ^{[1
]}

Tang, Wenjun ^{[1
,2
]}

机构：

[1] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Chem Biol, Shanghai 200032, Peoples R China

[2] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, Hangzhou 310024, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 146卷 / 40期

基金：

国家重点研发计划;

关键词：

DEPENDENT TRANSFER HYDROGENATION; SOLUBLE CARBONYL-COMPOUNDS; ALPHA-KETO ACIDS; CP-ASTERISK; REDUCTIVE AMINATION; COMPLEX; HYDRIDE;

D O I：

10.1021/jacs.4c09516

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of polymeric chiral diamine ligands are developed by diboron-templated asymmetric reductive couplings, and their iridium complexes Ir-polydiamines are efficient and recyclable catalysts for asymmetric transfer hydrogenation (ATH) of functionalized ketones, affording a series of optically active secondary alcohols in excellent enantioselectivities (up to 99% ee) and unprecedentedly high total TONs (12,000, six cycles). Ir-polydiamine catalysts with longer chains offered higher reactivities, providing a plausible deactivation mechanism and practical solutions of ATH for vitamin B5 and phenylephrine.

引用

收藏

页码：27736 / 27744

页数：9

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