Acetyl-11-Keto-β-Boswellic Acid and Incensole Acetate Attenuate Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress

被引：1

作者：

Sharifi, Mohammad Rahim ^{[1
]}

Hakimi, Zhara ^{[1
]}

Ghalibaf, Mohammad Hosein Eshaghi ^{[2
]}

Fazeli, Elham ^{[3
]}

Behshti, Farimah ^{[4
,5
]}

Marefati, Narges ^{[6
]}

Hosseini, Mahmoud ^{[7
]}

机构：

[1] Ghalib Univ, Fac Med, Dept Physiol, Herat, Afghanistan

[2] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran

[3] Islamic Azad Univ, Dept Biol, Mashhad Branch, Mashhad, Iran

[4] Torbat Heydariyeh Univ Med Sci, Neurosci Res Ctr, Torbat Heydariyeh, Iran

[5] Torbat Heydariyeh Univ Med Sci, Sch Med, Dept Physiol, Torbat Heydariyeh, Iran

[6] Baqiyatallah Univ Med Sci, Fac Med, Dept Physiol & Med Phys, Tehran, Iran

[7] Psychiat & Behav Sci Res Ctr, Sch Med, Dept Physiol, Azadi Sq, Mashhad, Iran

来源：

SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION | 2023年 / 34卷 / SUPPL 1期

关键词：

ACUTE-RENAL-FAILURE; SEPSIS; MECHANISMS; PROTECTS; DEFICITS; DISEASE; RESIN;

D O I：

10.4103/sjkdt.sjkdt_41_22

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Boswellia serrata has been used in traditional medicine to treat various inflammatory diseases. Acetyl-11-keto-beta-boswellic acid (AKBA) and incensole acetate (IA) are two active ingredients of B. serrata that possess anti-inflammatory and antioxidant activities. The present study aimed to investigate the protective effects of AKBA and IA against lipopolysaccharide (LPS)- induced acute kidney injury (AKI) in rats. Wistar rats were intraperitoneally pretreated with AKBA or IA for 2 weeks. After 30 min, an LPS injection was applied to induce AKI. Blood samples and kidney tissues were collected and used for biochemical assays. AKBA and IA not only significantly decreased interleukin-6 as a marker of renal inflammation but also attenuated the oxidative stress markers in kidney tissues. AKBA and IA also remarkably decreased serum creatinine and blood urea nitrogen. These results suggest that AKBA and IA have protective effects against AKI in rats through regulating inflammation and oxidative stress.

引用

页码：S142 / S152

页数：11

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