Large-scale genomic analysis of the domestic dog informs biological discovery

被引:1
作者
Buckley, Reuben M. [1 ]
Ostrander, Elaine A. [1 ]
机构
[1] NHGRI, NIH, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
ANALYSES REVEAL; VILLAGE DOGS; MUTATION; TRAITS; ORIGIN; CANCER; MODEL; VARIANTS; GENETICS; PROGRAMS;
D O I
10.1101/gr.278569.123
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent advances in genomics, coupled with a unique population structure and remarkable levels of variation, have propelled the domestic dog to new levels as a system for understanding fundamental principles in mammalian biology. Central to this advance are more than 350 recognized breeds, each a closed population that has undergone selection for unique features. Genetic variation in the domestic dog is particularly well characterized compared with other domestic mammals, with almost 3000 high-coverage genomes publicly available. Importantly, as the number of sequenced genomes increases, new avenues for analysis are becoming available. Herein, we discuss recent discoveries in canine genomics regarding behavior, morphology, and disease susceptibility. We explore the limitations of current data sets for variant interpretation, tradeoffs between sequencing strategies, and the burgeoning role of long-read genomes for capturing structural variants. In addition, we consider how large-scale collections of whole-genome sequence data drive rare variant discovery and assess the geographic distribution of canine diversity, which identifies Asia as a major source of missing variation. Finally, we review recent comparative genomic analyses that will facilitate annotation of the noncoding genome in dogs.
引用
收藏
页码:811 / 821
页数:11
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