Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer

被引：0
作者：
Wen, Weijia [1 ,2 ]
Yuan, Li [1 ,2 ]
Zhao, Xueyuan [1 ,2 ]
Jia, Yan [1 ,2 ]
Chen, Linna [1 ,2 ]
Jiang, Hongye [1 ,2 ]
Wang, Wei [1 ,2 ]
Zhang, Chunyu [1 ,2 ]
Yao, Shuzhong [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China
[2] Guangdong Prov Clin Res Ctr Obstetr & Gynecol Dis, Guangzhou, Guangdong, Peoples R China
来源：
GENOMICS | 2024年 / 116卷 / 05期
关键词：
Endometrial cancer; Circular RNA; Immune; Competing endogenous RNA; circRNA-miRNA-mRNA network; hsa_circ_0058230; CELLS; CERNA; TUMORS;
D O I：
10.1016/j.ygeno.2024.110931
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The clinical benefit of anti-programmed cell death protein 1 (PD-1)-based immunotherapy among patients with microsatellite instable (MSI) endometrial cancer (EC) precedes that of microsatellite stable (MSS) EC, the mechanisms of which have not been fully understood. Circular RNAs (circRNAs) were reported to modulate immune evasion in several types of malignancies, while their roles in the immune regulation in EC remain largely unknown. Here, we conducted circRNA array analysis and mRNA-Sequencing of 10 MSI EC samples and 10 MSS EC samples and identified 1083 differentially expressed circRNAs (DE-circRNAs) and 864 differentially expressed mRNAs, based on which we constructed a circRNA-miRNA-mRNA comprehensive network consisting of 35 DEcircRNAs, 56 predicted miRNAs and 24 differentially expressed mRNAs. Finally, we confirmed hsa_circ_0058230 being positively correlated with CD8+ T cells infiltration, suggesting that it might take a part in anti-tumor immunity in EC.
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页数：13
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