Adipose thermogenic mechanisms by cold, exercise and intermittent fasting: Similarities, disparities and the application in treatment

被引：0

作者：

Chen, Linshan ^{[1
]}

Liu, Longhua ^{[1
]}

机构：

[1] Shanghai Univ Sport, Sch Exercise & Hlth, Shanghai, Peoples R China

来源：

CLINICAL NUTRITION | 2024年 / 43卷 / 09期

关键词：

Adipose thermogenesis; Metabolic disorders; Cold; Exercise; Intermittent fasting; DIET-INDUCED OBESITY; HIGH-FAT DIET; MESSENGER-RNA EXPRESSION; SKELETAL-MUSCLE; METEORIN-LIKE; WHITE FAT; UCP1; TRANSCRIPTION; INSULIN-RESISTANCE; INDUCED LIPOKINE; ENDOCRINE ORGAN;

D O I：

10.1016/j.clnu.2024.07.024

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Given its nonnegligible role in metabolic homeostasis, adipose tissue has been the target for treating metabolic disorders such as obesity, diabetes and cardiovascular diseases. Besides its lipolytic function, adipose thermogenesis has gained increased interest due to the irreplaceable contribution to dissipating energy to restore equilibrium, and its therapeutic effects have been testified in various animal models. In this review, we will brief about the canonical cold-stimulated adipose thermogenic mechanisms, elucidate on the exercise- and intermittent fasting-induced adipose thermogenic mechanisms, with a focus on the similarities and disparities among these signaling pathways, in an effort to uncover the overlapped and specific targets that may yield potent therapeutic efficacy synergistically in improving metabolic health. (c) 2024 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

引用

页码：2043 / 2056

页数：14

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